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DOSIS TOLERANCIA [3 records]
Record 1 - internal organization data 2020-07-14
Record 1, English
Record 1, Subject field(s)
- Scientific Research
- General Medicine
Record 1, Main entry term, English
- therapeutic research
1, record 1, English, therapeutic%20research
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
Research [which may involve] testing of a new treatment for a disease, a new drug therapy or a new surgical procedure [on a human being]. 2, record 1, English, - therapeutic%20research
Record number: 1, Textual support number: 1 OBS
The aim of therapeutic research is to benefit the individual research participant or patient by treating or curing their condition ... the aim of non-therapeutic research is to benefit people other than the research participant. 3, record 1, English, - therapeutic%20research
Record 1, French
Record 1, Domaine(s)
- Recherche scientifique
- Médecine générale
Record 1, Main entry term, French
- recherche thérapeutique
1, record 1, French, recherche%20th%C3%A9rapeutique
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
La recherche thérapeutique est réalisée sur l'homme par des chercheurs médecins et pharmaciens qui travaillent le plus souvent à l'hôpital. Elle fait suite à la recherche fondamentale et à l'expérimentation animale : la recherche fondamentale permet de comprendre les mécanismes de la maladie et de trouver des moyens (médicaments ou autres) pour bloquer ces mécanismes. C'est la recherche thérapeutique qui permet, ensuite, de savoir si ces moyens sont efficaces contre la maladie. L'expérimentation animale permet de «sélectionner», sur un temps assez court, des nouveaux médicaments efficaces et de «se débarrasser» des médicaments qui s'avèrent être trop toxiques. Seule la recherche thérapeutique permettra ensuite d'étudier chez l'homme les médicaments les plus efficaces et, a priori, les moins toxiques. 2, record 1, French, - recherche%20th%C3%A9rapeutique
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Investigación científica
- Medicina
Record 1, Main entry term, Spanish
- investigación terapéutica
1, record 1, Spanish, investigaci%C3%B3n%20terap%C3%A9utica
correct, feminine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 DEF
Conjunto de los estudios preclínicos y clínicos puestos en marcha para caracterizar la dosis, el régimen de administración, la actividad y la tolerancia del agente utilizado solo o en asociación [...] y la caracterización de nuevos métodos quirúrgicos. 2, record 1, Spanish, - investigaci%C3%B3n%20terap%C3%A9utica
Record 2 - internal organization data 2007-12-19
Record 2, English
Record 2, Subject field(s)
- Medication
- Drugs and Drug Addiction
Record 2, Main entry term, English
- methadone
1, record 2, English, methadone
correct
Record 2, Abbreviations, English
Record 2, Synonyms, English
Record 2, Textual support, English
Record number: 2, Textual support number: 1 DEF
A synthetic opiate analgesic .... It is used in medicine as an analgesic, to suppress the cough reflex, in treatment of heroin or morphine withdrawal symptoms. 2, record 2, English, - methadone
Record 2, French
Record 2, Domaine(s)
- Médicaments
- Drogues et toxicomanie
Record 2, Main entry term, French
- méthadone
1, record 2, French, m%C3%A9thadone
correct, feminine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
Record 2, Textual support, French
Record number: 2, Textual support number: 1 CONT
La méthadone est un produit synthétique fabriqué à partir de la formule des alcaloïdes de l'opium [et elle] neutralise les symptômes de sevrage à l'héroïne. 1, record 2, French, - m%C3%A9thadone
Record 2, Spanish
Record 2, Campo(s) temático(s)
- Medicamentos
- Drogas y toxicomanía
Record 2, Main entry term, Spanish
- metadona
1, record 2, Spanish, metadona
correct, feminine noun
Record 2, Abbreviations, Spanish
Record 2, Synonyms, Spanish
Record 2, Textual support, Spanish
Record number: 2, Textual support number: 1 CONT
La metadona es un opioide, es decir, un narcótico sintético de acción parecida a los opiáceos(morfina, etcétera), pero que no deriva del opio. Los adictos a la heroína son dependientes de opiáceos y sufren los síntomas de la abstinencia si la concentración de esta droga en sangre baja de cierto nivel. Una dosis apropiada de metadona reduce los síntomas de abstinencia. En el tratamiento mantenido con metadona, se induce la tolerancia a una dosis constante de metadona que es suficientemente alta para bloquear la acción narcótica y eufórica de los opiáceos. 1, record 2, Spanish, - metadona
Record 3 - internal organization data 1998-08-20
Record 3, English
Record 3, Subject field(s)
- Environmental Studies and Analyses
- Toxicology
Record 3, Main entry term, English
- median tolerance limit
1, record 3, English, median%20tolerance%20limit
correct
Record 3, Abbreviations, English
- TLm 1, record 3, English, TLm
correct
Record 3, Synonyms, English
Record 3, Textual support, English
Record number: 3, Textual support number: 1 DEF
In a biological assay, the concentration of a toxic material at which 50% of the test organisms survive. 2, record 3, English, - median%20tolerance%20limit
Record 3, French
Record 3, Domaine(s)
- Études et analyses environnementales
- Toxicologie
Record 3, Main entry term, French
- tolérance limite moyenne
1, record 3, French, tol%C3%A9rance%20limite%20moyenne
correct, feminine noun
Record 3, Abbreviations, French
- TLm 2, record 3, French, TLm
correct
Record 3, Synonyms, French
- tolérance limite médiane 3, record 3, French, tol%C3%A9rance%20limite%20m%C3%A9diane
correct, feminine noun
- tolérance moyenne 4, record 3, French, tol%C3%A9rance%20moyenne
feminine noun
- tolérance 50 % 5, record 3, French, tol%C3%A9rance%2050%20%25
feminine noun
- limite de tolérance médiane 6, record 3, French, limite%20de%20tol%C3%A9rance%20m%C3%A9diane
feminine noun
Record 3, Textual support, French
Record number: 3, Textual support number: 1 DEF
Niveau de tolérance correspondant à la teneur à laquelle 50 p. 100 des sujets d'un test survivent au bout d'un temps donné. 7, record 3, French, - tol%C3%A9rance%20limite%20moyenne
Record number: 3, Textual support number: 1 OBS
La tolérance moyenne est symbolisée par les lettres TLm ou TL 50 (voir cette fiche). 8, record 3, French, - tol%C3%A9rance%20limite%20moyenne
Record 3, Spanish
Record 3, Campo(s) temático(s)
- Estudios y análisis del medio ambiente
- Toxicología
Record 3, Main entry term, Spanish
- límite de tolerancia mediano
1, record 3, Spanish, l%C3%ADmite%20de%20tolerancia%20mediano
correct, masculine noun
Record 3, Abbreviations, Spanish
- LTm 1, record 3, Spanish, LTm
correct, see observation
Record 3, Synonyms, Spanish
Record 3, Textual support, Spanish
Record number: 3, Textual support number: 1 OBS
LTm. 1, record 3, Spanish, - l%C3%ADmite%20de%20tolerancia%20mediano
Record number: 3, Textual support number: 1 CONT
La medida prescrita de toxicidad aguda es el límite de tolerancia mediano(LTm) que se denomina dosis letal del 50 por ciento(DL50). Ésta es la concentración de material sometido a prueba en la cual el 50 por ciento de los peces de prueba sobrevive en un periodo específico de exposición(normalmente de 48 a 96 h). 1, record 3, Spanish, - l%C3%ADmite%20de%20tolerancia%20mediano
Record number: 3, Textual support number: 2 OBS
límite de tolerancia : máximo nivel de concentración de una sustancia contaminante que puede soportarse en un ambiente, durante un tiempo determinado, sin que se cause daños a la comunidad biótica. 2, record 3, Spanish, - l%C3%ADmite%20de%20tolerancia%20mediano
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