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TERAPIA GENICA SUSTITUCION [2 records]
Record 1 - internal organization data 2009-06-19
Record 1, English
Record 1, Subject field(s)
- Biotechnology
- Genetics
Record 1, Main entry term, English
- chimeraplasty
1, record 1, English, chimeraplasty
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
A method of gene therapy based upon the use of a molecule called a chimeraplast, a synthetic blend of DNA [deoxyribonucleic acid] and the related molecule RNA [ribonucleic acid], to trick the patient's own cells to remedy a gene defect. 1, record 1, English, - chimeraplasty
Record 1, French
Record 1, Domaine(s)
- Biotechnologie
- Génétique
Record 1, Main entry term, French
- chiméraplastie
1, record 1, French, chim%C3%A9raplastie
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Technique qui consiste à transférer un oligonucléotide chimérique fait d'ADN [acide désoxyribonucléique] et d'ARN [acide ribonucléique] qui s'hybride à la région à corriger et déclenche le processus physiologique de réparation. 2, record 1, French, - chim%C3%A9raplastie
Record 1, Key term(s)
- chimèraplastie
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Biotecnología
- Genética
Record 1, Main entry term, Spanish
- quimeroplastia
1, record 1, Spanish, quimeroplastia
correct, feminine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 DEF
Método diseñado para crear determinados cambios en un locus diana de una secuencia de ADN, de interés tanto para la terapia génica como para la investigación de la función de los genes. Consiste en introducir un ácido nucleico sintético formado por ADN intercalado con pequeñas cantidades de ARN, en la célula Diana donde se aparea con la secuencia génica Diana. Se desencadena entonces el mecanismo celular de reparación del ADN, dando lugar a la sustitución de la secuencia nativa por la sintética. 1, record 1, Spanish, - quimeroplastia
Record 2 - internal organization data 2008-10-28
Record 2, English
Record 2, Subject field(s)
- Genetics
- Biotechnology
Record 2, Main entry term, English
- replacement gene therapy
1, record 2, English, replacement%20gene%20therapy
correct
Record 2, Abbreviations, English
Record 2, Synonyms, English
Record 2, Textual support, English
Record number: 2, Textual support number: 1 CONT
It is anticipated that replacement gene therapy would be most appropriate for autosomal or sex-linked recessive mutations where loss of the normal gene product results in disease. 2, record 2, English, - replacement%20gene%20therapy
Record 2, French
Record 2, Domaine(s)
- Génétique
- Biotechnologie
Record 2, Main entry term, French
- thérapie génique de remplacement
1, record 2, French, th%C3%A9rapie%20g%C3%A9nique%20de%20remplacement
correct, feminine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
Record 2, Textual support, French
Record number: 2, Textual support number: 1 OBS
Théoriquement, la thérapie génique peut revêtir plusieurs formes dont l'addition génique, la modification génique in situ et le remplacement génique. Cependant, dans les applications médicales actuelles du génie génétique, seule l'addition de gènes est praticable. 2, record 2, French, - th%C3%A9rapie%20g%C3%A9nique%20de%20remplacement
Record 2, Spanish
Record 2, Campo(s) temático(s)
- Genética
- Biotecnología
Record 2, Main entry term, Spanish
- terapia génica de sustitución
1, record 2, Spanish, terapia%20g%C3%A9nica%20de%20sustituci%C3%B3n
correct, feminine noun
Record 2, Abbreviations, Spanish
Record 2, Synonyms, Spanish
- terapia génica de reemplazamiento 2, record 2, Spanish, terapia%20g%C3%A9nica%20de%20reemplazamiento
correct, feminine noun
Record 2, Textual support, Spanish
Record number: 2, Textual support number: 1 CONT
Las bases metodológicas de la terapia génica se sustentan en la inserción de un determinado gen [...] Así, el fin último de todo ello será reemplazar la función alterada, bien mediante la introducción del gen sano y completo, en cuyo caso hablaríamos de terapia génica de adición, o bien mediante la reparación puntual de la mutación con sondas oligonucleotídicas de ácido desoxirribonucleico(ADN) o ribonucleico(ARN), en cuyo caso procederíamos mediante terapia génica de sustitución. 3, record 2, Spanish, - terapia%20g%C3%A9nica%20de%20sustituci%C3%B3n
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