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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Proximal convoluted tubule diuretics. The proximal convoluted tubule is the primary site for NA+ [sodium ion] reabsorption and seems a likely site for effective diuretic action. However, the number of downstream reabsorption sites limits the effectiveness of any diuretic targeting this region. Carbonic anhydrase inhibitors are the only commonly used diuretics that particularly target this region although they are rarely used primarily as diuretics. They work by blocking the enzyme carbonic anhydrase, which acts to help reabsorb bicarbonate in the proximal tubule.  2, record 1, English, - proximal%20diuretic

Record number: 1, Textual support number: 1 OBS

Acetazolamide is an example of a proximal diuretic.  4, record 1, English, - proximal%20diuretic

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Les diurétiques proximaux : ce sont les inhibiteurs de l'anhydrase carbonique(acétazolamide) et les substances osmotiques(mannitol).  2, record 1, French, - diur%C3%A9tique%20proximal

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 OBS

A carbonic anhydrase type of diuretic, useful in treating glaucoma.  2, record 2, English, - acetazolamide

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

Diurétique inhibiteur de l'anhydrase carbonique; essentiel à la formation de l'humeur aqueuse. Il est utilisé dans le traitement du glaucome.  1, record 2, French, - ac%C3%A9tazolamide

Record number: 2, Textual support number: 1 OBS

Source MVISI-F : Le nouveau dictionnaire de la vision par Michel Millodot, Médiacom Vision Éditeur, 1997.  2, record 2, French, - ac%C3%A9tazolamide

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

Inhibition of enzyme action based solely on the concentration of the inhibitor; substrate concentration is not a factor. The inhibitors combine with the enzyme on a site other than that utilized by the substrate.  2, record 3, English, - noncompetitive%20inhibition

Record number: 3, Textual support number: 1 CONT

In non-competitive inhibition the binding of the inhibitor substance is thought to induce a conformational change in the enzyme molecule which does not interfere with the attachment of the substrate to the active site, but which greatly reduces the catalytic activity of the enzyme.  2, record 3, English, - noncompetitive%20inhibition

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Inhibition enzymatique où l’inhibiteur et le substrat n’ont pas de structures apparentées et l’inhibiteur se lie à un site différent de celui du substrat. Elle ne peut être renversée par des concentrations élevées du substrat.  2, record 3, French, - inhibition%20non%20comp%C3%A9titive

Record number: 3, Textual support number: 1 CONT

Le type le plus courant d’inhibition non compétitive est produit par les réactifs qui peuvent se fixer réversiblement, hors du site actif, sur un groupement fonctionnel de l’enzyme indispensable au maintien de la conformation tridimensionnelle active de la molécule enzymatique. Certains enzymes possédant un groupement -SH essentiel sont inhibés de façon non compétitive par les métaux lourds. Ces groupements -SH doivent donc être intacts pour que l’enzyme conserve sa conformation active normale.  3, record 3, French, - inhibition%20non%20comp%C3%A9titive

Record number: 3, Textual support number: 1 OBS

L'acétazolamide, diurétique fort utilisé, agit en inhibant de façon non compétitive l'anhydrase carbonique au niveau du rein.  4, record 3, French, - inhibition%20non%20comp%C3%A9titive

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 OBS

The enzyme responsible for the addition of water to carbon dioxide to form carbonic acid is carbonic anhydrase, which is present in high concentrations in corals.  1, record 4, English, - carbonic%20anhydrase

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 OBS

L'enzyme(l'anhydrase carbonique) qui assure la transformation du gaz carbonique en acide carbonique existe à de fortes concentrations dans les coraux.  1, record 4, French, - anhydrase%20carbonique

Record 4,  Textual support,  Spanish