TERMIUM Plus®

The Government of Canada’s terminology and linguistic data bank.

CRYOGLOBULINE [2 records]

Record 1 2003-11-06

English

Subject field(s)
  • Blood
  • Biotechnology
DEF

A serum globulin (invariably an immunoglobulin) that precipitates at low temperatures (e.g., 4°C) and redissolves at 37°C.

OBS

Cryoglobulins are classified as Type I, monoclonal immunoglobulins; Type II, immune complexes involving immunoglobulins with antibody activity against polyclonal immunoglobulins; or Type III, immune complexes involving polyclonal immunoglobulins; in most cases, these are globulin-antiglobulin immune complexes like type II complexes. Types I and II occur in plasma cell dyscrasias and lymphoproliferative disorders Types II and III occur in autoimmune disease such as rheumatoid arthritis, systemic lupus erythematosus and Sjogren's syndrome.

French

Domaine(s)
  • Sang
  • Biotechnologie
DEF

Immunoglobuline ayant la propriété de précipiter "à froid" à des températures variables selon le type de cryoglobuline au-dessous de 37°C, et de se redissoudre à 37°C.

OBS

On distingue les cryoglobulines monoclonales des cryoglobulines mixtes, de type IgM-IgG où, en général, l’IgG est l’antigène et l’IgM un anticorps anti-IgG (cette IgM pouvant être monoclonale ou non).

Spanish

Campo(s) temático(s)
  • Sangre
  • Biotecnología
DEF

Globulinas que precipitan espontáneamente cuando la temperatura del suero baja de 37º C.

Save record 1

Record 2 2002-04-24

English

Subject field(s)
  • Immunology
CONT

The plasma cell disorders are characterized by the secretion of electrophoretically and immunologically homogeneous (monoclonal) proteins. Each monoclonal protein (M-protein, myeloma protein, or paraprotein) consists of two heavy (H) polypeptide chains of the same class and subclass and two light (L) polypeptide chains of the same type.

French

Domaine(s)
  • Immunologie
CONT

La paraprotéine est mise en évidence sur l'électrophorèse des protéines, son caractère monoclonal est reconnu grâce à l'immunoélectrophorèse. Parfois il s’agit d’une cryoglobuline, soit polyclonal(cryoglobuline mixte), soit monoclonal. Ces paraprotéines peuvent se rencontrer dans le cadre : d’une gammapathie monoclonale de cause inconnue [...] d’un myélome multiple [...] d’une macroglobulinémie de Waldenström [...]

Spanish

Campo(s) temático(s)
  • Inmunología
Save record 2

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