TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Definition of Controlled Release. A system that: delivers an agent at a controlled rate for an extended time; might localize drug action by spatial placement near where it is needed; might target drug action by using techniques to deliver drug to a particular cell type.  4, record 1, English, - controlled%20drug%20delivery%20system

Record number: 1, Textual support number: 1 OBS

Controlled drug delivery occurs when a polymer, whether natural or synthetic, is judiciously combined with a drug or other active agent in such a way that the active agent is released from the material in a predesigned manner. The release of the active agent may be constant over a long period, it may be cyclic over a long period, or it may be triggered by the environment or other external events. In any case, the purpose behind controlling the drug delivery is to achieve more effective therapies while eliminating the potential for both under- and overdosing.  5, record 1, English, - controlled%20drug%20delivery%20system

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

[...] les systèmes à libération contrôlée dont le principe consiste à inclure une molécule biologiquement active au sein d’une matrice ou d’un réservoir capable d’assurer sa libération progressive au niveau du site d’administration (tube digestif, peau, muscle, etc...), si possible selon un profil cinétique donné.  4, record 1, French, - syst%C3%A8me%20de%20lib%C3%A9ration%20contr%C3%B4l%C3%A9e%20de%20m%C3%A9dicaments

Record number: 1, Textual support number: 1 OBS

La conception de systèmes de libération contrôlée de médicaments est l'un des grands domaines d’application des nanotechnologies. Depuis quelques années, il est possible d’administrer des hormones peptidiques(LH-RH, hormones de croissance,...) grâce à des micro-capsules : les peptides actifs sont enfermés dans une coque faite d’acides lactiques ou de polymères composés d’acides lactiques et glycoliques. La libération de l'hormone dépend de la cinétique de dégradation des polymères.  5, record 1, French, - syst%C3%A8me%20de%20lib%C3%A9ration%20contr%C3%B4l%C3%A9e%20de%20m%C3%A9dicaments

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Somatostatin (also known as somatotropin release-inhibiting factor [SRIF]) is a tetradecapeptide; a 28-amino acid precursor [which] also has GH [growth hormone] inhibitory properties. Somatostatin blocks the rise in GH that occurs with all stimuli in a dose-dependent manner.  2, record 2, English, - somatostatin

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

Hormone inhibitrice de la sécrétion hypophysaire de l'hormone de croissance et de l'hormone thyréotrope. Au niveau du pancréas, elle inhibe la libération d’insuline, de glucagon et de gastrine.  2, record 2, French, - somatostatine

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

While somatostatin inhibits release of growth hormone by the anterior pituitary, growth hormone releasing hormone (GHRH) stimulates the release of growth hormone.  2, record 3, English, - growth%20hormone%20releasing%20hormone

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

La sécrétion de l’hormone de croissance est stimulée par la GHRH (growth hormone releasing hormone) ou somatocrinine, sécrétée par l’hypothalamus d’une manière pulsatile et selon un cycle circadien avec un maximum durant le sommeil lent.  2, record 3, French, - hormone%20de%20lib%C3%A9ration%20de%20l%27hormone%20de%20croissance

Record number: 3, Textual support number: 2 CONT

Une infusion de GHRH(hormone de libération de l'hormone de croissance).  1, record 3, French, - hormone%20de%20lib%C3%A9ration%20de%20l%27hormone%20de%20croissance

Record 3,  Textual support,  Spanish