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HYBRIDATION GENOMIQUE COMPARATIVE [2 records]

Record 1 1997-08-29

English

Subject field(s)
  • Genetics
CONT

Breast cancer progression is determined by a complex pattern of multiple genetic aberrations the association of which with patient prognosis is unknown. In this study, we have undertaken a genome-wide screening to detect genetic changes associated with clinical outcome in node-negative breast cancer. Comparative genomic hybridization was used to screen for DNA sequence gains and losses across all human chromosomes in 23 tumors ...

French

Domaine(s)
  • Génétique
CONT

La séquence FISH(hybridation en fluorescence in situ) et le développement des techniques fondées sur son principe sont en train de modifier radicalement les méthodes d’analyse de la génétique. Parmi celles-ci, l'hybridation génomique comparative(CGH) constitue un outil performant d’exploration du génome.

CONT

La CGH est une méthode permettant d’évaluer une modification du nombre de copies d’ADN dans un génome pathologique [...] Son principe est fondé sur la compétition, lors de l’hybridation, entre un ADN génomique normal et un ADN génomique pathologique.

Spanish

Save record 1

Record 2 1997-07-16

English

Subject field(s)
  • Genetics
CONT

The LBNL/UCSF Resource for Molecular Cytogenetics has been created to facilitate the application of molecular cytogenetics in clinical and biological studies. Work is being pursued in three areas: Development and application of improved hybridization technology, selection of probes optimized for use in fluorescence in situ hybridization (FISH), and development of digital imaging microscopy.

OBS

Resource for Molecular Cytogenetics Cancer Center, University of California, San Francisco Lawrence Berkeley National Laboratory, Berkeley California.

French

Domaine(s)
  • Génétique
CONT

Cependant deux nouvelles techniques de cytogénétique moléculaire utilisant la FISH ont été développées au cours des cinq dernières années : l'hybridation génomique comparative et le caryotype spectral.

Spanish

Save record 2

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