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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 OBS

Naturally occurring, non-essential amino acid; M.W. 105.09. It may be synthesized from glucose and is interconvertible with glycine. It is a substrate in the formation of cystathionine. Present in many proteins, it provides a side-chain hydroxyl group, which permits modification of the protein by phosphorylation or glycosylation.  7, record 1, English, - L%2Dserine

Record number: 1, Textual support number: 2 OBS

Ser and S are abbreviations used to denote the amino acid serine in amino acid sequences and elsewhere.  8, record 1, English, - L%2Dserine

Record number: 1, Textual support number: 3 OBS

L-serine: form recommended by the IUPAC (International Union of Pure and Applied Chemistry).  6, record 1, English, - L%2Dserine

Record number: 1, Textual support number: 4 OBS

(S)-2-amino-3-hydroxypropanoic acid: form recommended by the IUPAC (International Union of Pure and Applied Chemistry) for the systematic name corresponding to the CAS number indicated on the present record.  6, record 1, English, - L%2Dserine

Record number: 1, Textual support number: 5 OBS

alpha: This word must be replaced by the corresponding Greek letter or italicized.  6, record 1, English, - L%2Dserine

Record number: 1, Textual support number: 6 OBS

L: This letter is a small capital.  6, record 1, English, - L%2Dserine

Record number: 1, Textual support number: 7 OBS

(S): This letter must be italicized.  6, record 1, English, - L%2Dserine

Record number: 1, Textual support number: 8 OBS

Chemical formula: C₃H₇NO₃  9, record 1, English, - L%2Dserine

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 OBS

Acide aminé glucoformateur non indispensable, possédant une fonction alcool. Son dérivé phosphorylé, la phosphosérine, entre dans la composition des phosphoprotéines. Estérifiée par l'acide phosphatidique, elle donne la phosphatidyl-sérine qui est un important phospholipide.  5, record 1, French, - L%2Ds%C3%A9rine

Record number: 1, Textual support number: 1 CONT

La sérine existe dans les sites catalytiques de nombreuses enzymes protéolytiques (trypsine, chymotrypsine) et de nombreuses enzymes hydrolytiques (phosphatases alcalines, acétylcholinestérases). Elle est à l’origine de la synthèse des phosphatides complexes. La L-sérine, ou S-sérine, est le composé dont la configuration absolue sert de référence pour tous les aminoacides naturels, qui dérivent de la L-sérine en remplaçant CH₂, OH par un autre groupement.  6, record 1, French, - L%2Ds%C3%A9rine

Record number: 1, Textual support number: 2 OBS

L-sérine : forme recommandée par l’UICPA (Union internationale de chimie pure et appliquée).  2, record 1, French, - L%2Ds%C3%A9rine

Record number: 1, Textual support number: 3 OBS

acide (S)-2-amino-3-hydroxypropanoïque : forme recommandée par l’UICPA (Union internationale de chimie pure et appliquée) pour le nom systématique correspondant au numéro CAS indiqué sur la présente fiche.  2, record 1, French, - L%2Ds%C3%A9rine

Record number: 1, Textual support number: 4 OBS

alpha : Ce mot doit être remplacé par la lettre grecque correspondante ou s’écrire en italique.  2, record 1, French, - L%2Ds%C3%A9rine

Record number: 1, Textual support number: 5 OBS

L : Cette lettre est une petite majuscule.  2, record 1, French, - L%2Ds%C3%A9rine

Record number: 1, Textual support number: 6 OBS

(S) : Cette lettre s’écrit en italique.  2, record 1, French, - L%2Ds%C3%A9rine

Record number: 1, Textual support number: 7 OBS

Formule chimique : C₃H₇NO₃  7, record 1, French, - L%2Ds%C3%A9rine

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 OBS

Aminoácido no esencial encontrado en muchas proteínas del cuerpo. Es un precursor de los aminoácidos glicina y cisteína.  2, record 1, Spanish, - serina

Record number: 1, Textual support number: 2 OBS

Fórmula química: C₃H₇NO₃  3, record 1, Spanish, - serina

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

The esterification of compounds with phosphoric acid.  2, record 2, English, - phosphorylation

Record number: 2, Textual support number: 1 CONT

One such modification [molecular modification of proteins] is phosphorylation, the addition or attachment of a phosphate group. Phosphorylation has a profound effect on the function of proteins. It is commonly stimulated by transmitters and drugs that act via G protein-coupled receptors.  3, record 2, English, - phosphorylation

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

Réaction chimique comportant la fixation d’un radical phosphoryle sur un composé chimique.  3, record 2, French, - phosphorylation

Record number: 2, Textual support number: 1 CONT

L’une de ces modifications [transformations moléculaires des protéines] est la phosphorylation des protéines, la liaison d’un groupe phosphate, qui modifie notablement la fonction des protéines, et est souvent stimulée par des médiateurs ou par des drogues agissant par l’intermédiaire de facteurs couplés à des protéines G.  4, record 2, French, - phosphorylation

Record 2,  Textual support,  Spanish

Record number: 2, Textual support number: 1 DEF

Proceso metabólico de esterificación de componentes orgánicos con ácido ortofosfórico.  2, record 2, Spanish, - fosforilaci%C3%B3n

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

The subunit of a regulatory enzyme that has no enzymatic activity but binds the effector.  1, record 3, English, - regulatory%20subunit

Record number: 3, Textual support number: 1 CONT

The aspartate transcarbamoylase of E. coli ... can be dissociated ... to yield two identical catalytic subunits and three identical regulatory subunits.... The mixture retains catalytic activity but the reaction is not inhibited by CTP so long as the catalytic and regulatory subunits are detached from each other.  2, record 3, English, - regulatory%20subunit

Record number: 3, Textual support number: 1 OBS

See "catalytic subunit".  1, record 3, English, - regulatory%20subunit

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Sous-unité d’un enzyme allostérique capable de fixer l’effecteur allostérique (mais dépourvue d’activité catalytique).  2, record 3, French, - sous%2Dunit%C3%A9%20r%C3%A9gulatrice

Record number: 3, Textual support number: 1 CONT

La principale action du cAMP dans le métabolisme est de stimuler l'activité des protéines kinases, un groupe d’enzymes qui catalyse la phosphorylation des protéines. [...] L'enzyme possède deux sous-unités : l'une catalytique et l'autre, régulatrice et qui peut lier le cAMP. En absence de cAMP, les sous-unités régulatrice et catalytique forment un complexe enzymatiquement inactif. La liaison du cAMP à la sous-unité régulatrice entraîne un changement conformationnel et dissocie le complexe. La sous-unité catalytique ainsi libérée est enzymatiquement active et elle phosphoryle les autres enzymes.  3, record 3, French, - sous%2Dunit%C3%A9%20r%C3%A9gulatrice

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

The trivalent radical O=P≡.  2, record 4, English, - phosphoryl

Record number: 4, Textual support number: 2 DEF

The radical pO, regarded as the typical nucleus of certain compounds.  3, record 4, English, - phosphoryl

Record number: 4, Textual support number: 1 OBS

Prefix incorrectly used to signify a phosphate (e.g., phosphorylcholine) in place of the correct O-phosphono-or phospho-.  3, record 4, English, - phosphoryl

Record number: 4, Textual support number: 2 OBS

Derived terms: phosphorylase, phosphorylate, phosphorylation.  2, record 4, English, - phosphoryl

Record number: 4, Textual support number: 3 OBS

Chemical formula: PO3²  4, record 4, English, - phosphoryl

Record number: 4, Textual support number: 1 PHR

Phosphoryl chloride, choline, peptide, transfer.  2, record 4, English, - phosphoryl

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Radical trivalent formé d’un atome de phosphore et un atome d’oxygène.  2, record 4, French, - phosphoryle

Record number: 4, Textual support number: 1 OBS

Dérivés :phosphorylé(adjectif), phosphoryler(verbe)  3, record 4, French, - phosphoryle

Record number: 4, Textual support number: 2 OBS

Formule chimique : PO3²  4, record 4, French, - phosphoryle

Record number: 4, Textual support number: 1 PHR

Trichlorure de phosphoryle.  3, record 4, French, - phosphoryle

Record number: 4, Textual support number: 2 PHR

Groupement phosphoryle.  3, record 4, French, - phosphoryle

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

A protein kinase [that transduces] the cellular signals [promoting] lipid hydrolysis.  1, record 5, English, - protein%20kinase%20C

Record number: 5, Textual support number: 1 OBS

[Protein kinase C is a] 80kDa [kilodaltons] enzyme... recruited to the plasma membrane by diacylglycerol and, in many cases, by calcium. The enzyme is activated by diacylglycerol and phospholipid (usually PS [phosphatidylserine]) and is thought to undergo a conformational change upon binding to the membrane. PKC [protein kinase C] phosphorylates a variety of target proteins which control growth and cellular differentiation.  1, record 5, English, - protein%20kinase%20C

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

Après activation, la protéine kinase C est transférée du cytoplasme vers la membrane où elle phosphoryle des protéines sur les résidus sérine et thréonine.  1, record 5, French, - prot%C3%A9ine%20kinase%20C

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

The principle factor responsible for the transcriptional state of the c-fos proto-oncogene is the serum response factor (SRF) which binds a conserved DNA sequence called serum response element (SRE) present in the promoter region of the c-fos gene. In order to elucidate the molecular basis of this interaction, we have solved the crystal structure of a recombinant SRF-SRE complex (Nature, 376:490-298, 1995).  3, record 6, English, - serum%20response%20factor

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

La MAP kinase activée phosphoryle des protéines kinases activées sur la protéine ribosomique S6, la p90rsk., l'activant à son tour. Ces deux kinases sont alors transférées dans le noyau. La MAP kinase phosphoryle le facteur TCF/Elk-1, un partenaire de SRF(serum response factor) qui intervient dans la stimulation de gènes appelés «à réponse ultraprécoce» dont le prototype est le gène c-fos.  1, record 6, French, - facteur%20SRF

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

Technique that can be employed in the determination of an unknown sequence that flank a region of known sequences.  4, record 7, English, - inverted%20polymerase%20chain%20reaction

Record number: 7, Textual support number: 1 OBS

The template target sequence is digested with a suitable restriction enzyme that cuts the template outside the known sequence but in the region of the unknown sequence. PCR is carried out using two primers which anneal to the ends of the known sequence but reversed in their direction with respect to their normal orientation in a normal PCR reaction. This leads to the amplification of the region of the unknown sequence.  4, record 7, English, - inverted%20polymerase%20chain%20reaction

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 CONT

Le principe même de la mutagénèse dirigée par IPCR nécessite la purification préalable des oligonucléotides utilisés. En effet, la présence de formes n-1, n-2 ou n-x même très minoritaire induirait la formation de mutations supplémentaires par délétion de une, deux ou x bases ors de 12 PCR.  1, record 7, French, - PCR%20inverse

Record number: 7, Textual support number: 2 CONT

Le produit final d’une PCR inverse(amorces tête-bêche) est phosphoryle ligué et transformé.  1, record 7, French, - PCR%20inverse

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

physiologically, the mitochondrion passes from a conformational stage called orthodox into that called contraction. In the orthodox conformation, found at low external ADP, the matrix fills the entire volume of the inner compartment, and the crests may be seen clearly. In this stage the organelle does not phosphorylate.  1, record 8, English, - orthodox%20conformation

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

physiologiquement, la mitochondrie passe d’un état conformationnel appelé orthodoxe à un autre appelé condensé. Dans la conformation orthodoxe, alors que la concentration de l'ADP externe est faible, la matrice occupe le volume total du compartiment interne et les crêtes sont clairement visibles. Dans cet état, l'organite ne phosphoryle pas.  1, record 8, French, - conformation%20orthodoxe

Record 8,  Textual support,  Spanish