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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

An enzyme found in the liver and muscle cell membranes, which catalyses the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP) plus pyrophosphate, and is activated by many hormones.  2, record 1, English, - adenylcyclase

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Enzyme existant dans les membranes cellulaires, activant la formation de l’AMP3’ 5’-cyclique à partir de l’ATP.  1, record 1, French, - ad%C3%A9nylcyclase

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 DEF

Enzima encargada de catalizar la formación de AMP cíclico a partir de ATP.  1, record 1, Spanish, - adenilato%20ciclasa

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

A protein, with four binding sites for Ca²+, that mediates the action of Ca²+ as an intracellular second messenger in all eukaryotic cells; M.W. 16,700.  2, record 2, English, - calmodulin

Record number: 2, Textual support number: 1 OBS

Binding of calcium to calmodulin causes a conformational change, converting it to an active form that can bind to various effector enzymes, converting them in turn to an active conformation. One example is the Ca-dependent ATPase, which pumps Ca²+ out of cells and is turned on by activated calmodulin.  2, record 2, English, - calmodulin

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Lorsque le neurone sensoriel est actif, sa concentration en ions calcium augmente. Les ions calcium se lient à la calmoduline, qui s’associe alors à l'adénylate cyclase, augmentant ainsi la synthèse d’AMP cyclique.  2, record 2, French, - calmoduline

Record number: 2, Textual support number: 2 CONT

Cette sous-unité est identique à la calmoduline, une protéine impliquée dans la régulation de nombreux articles Ca2+ [Ca exposant 2+] dépendants.  3, record 2, French, - calmoduline

Record 2,  Textual support,  Spanish

Record number: 2, Textual support number: 1 DEF

Proteína ubicua moduladora del calcio intracelular que desempeña un papel fundamental en la regulación de una gran variedad de procesos biológicos.  2, record 2, Spanish, - calmodulina

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Once in the cell, calcium binds to a protein called calmodulin, which amplifies the activation of the enzyme adenylyl cyclase by serotonin. When calcium/calmodulin binds to the adenylyl cyclase, the enzyme generates more cyclic AMP. This capacity makes adenylyl cyclase an important convergence site for the conditioned and the unconditioned stimuli. The conditioned and the unconditioned stimuli are represented within the cell by the convergence of two different signals (calcium and serotonin) on the same enzyme.  1, record 3, English, - convergence%20site

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

La facilitation du conditionnement provient essentiellement de l'entrée des ions calcium dans les neurones sensoriels : les ions calcium s’y lient à la calmoduline, une protéine qui amplifie l'activation de l'adénylate cyclase; cette dernière, qui catalyse la synthèse de l'AMP cyclique, constitue ainsi le point de convergence des stimuli conditionnel et inconditionnel. Les stimuli conditionnel et inconditionnel transmettent aux neurones sensoriels deux signaux différents(l'entrée d’ions calcium et la fixation de la sérotonine sur son récepteur, respectivement) qui convergent sur la même enzyme.  1, record 3, French, - point%20de%20convergence

Record 3,  Textual support,  Spanish