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BI-RG-587 [2 records]
Record 1 - internal organization data 2005-05-04
Record 1, English
Record 1, Subject field(s)
- Medication
Record 1, Main entry term, English
- tetrahydro-imidazo-benzodiazepine-2-one and-thione
1, record 1, English, tetrahydro%2Dimidazo%2Dbenzodiazepine%2D2%2Done%20and%2Dthione
correct
Record 1, Abbreviations, English
- TIBO 1, record 1, English, TIBO
correct
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
TIBO: Tetrahydro-imidazo-benzodiazepine-2-one and-thione. TIBO derivatives are synthetic compounds found to have anti-HIV-1 activity and, to date, few toxic side effects. These compounds, under study currently, are reverse transcriptase inhibitors that interfere with replication of HIV. 1, record 1, English, - tetrahydro%2Dimidazo%2Dbenzodiazepine%2D2%2Done%20and%2Dthione
Record number: 1, Textual support number: 1 OBS
TIBO derivatives: New class of antivirals being developed by Jannsen Pharmaceuticals in Belgium. 2, record 1, English, - tetrahydro%2Dimidazo%2Dbenzodiazepine%2D2%2Done%20and%2Dthione
Record 1, Key term(s)
- TIBO derivative
Record 1, French
Record 1, Domaine(s)
- Médicaments
Record 1, Main entry term, French
- tétrahydro-imidazo-benzodiazepin-one
1, record 1, French, t%C3%A9trahydro%2Dimidazo%2Dbenzodiazepin%2Done
correct
Record 1, Abbreviations, French
- T.I.B.O. 1, record 1, French, T%2EI%2EB%2EO%2E
correct
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
les T. I. B. O.(tétrahydro-imidazo-benzodiazepin-one) sont des inhibiteurs hautement spécifiques de la réplication du V. I. H.-1 mais pas de celle de V. I. H.-2 ou d’autres rétrovirus. Ces T. I. B. O. sont atoxiques en dehors d’un effet sédatif. Un de ces produits est le BI-RG-587 du laboratoire Boehringer Ingelheim. Après avoir été exclusivement administrés en perfusion intraveineuse, les premiers essais per os des T. I. B. O. ont eu lieu début 91. 1, record 1, French, - t%C3%A9trahydro%2Dimidazo%2Dbenzodiazepin%2Done
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Medicamentos
Record 1, Main entry term, Spanish
- tetrahidro imidizol benzo diazepino
1, record 1, Spanish, tetrahidro%20imidizol%20benzo%20diazepino
masculine noun
Record 1, Abbreviations, Spanish
- TIBO 1, record 1, Spanish, TIBO
masculine noun
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 CONT
Los compuestos derivados del TIBO son altamente selectivos contra la transcriptasa reversa del VIH ya que inhiben la transcripción del ARN del virus al ADN de la célula. 1, record 1, Spanish, - tetrahidro%20imidizol%20benzo%20diazepino
Record 2 - internal organization data 2004-11-16
Record 2, English
Record 2, Subject field(s)
- Medication
Record 2, Main entry term, English
- nevirapine
1, record 2, English, nevirapine
correct
Record 2, Abbreviations, English
Record 2, Synonyms, English
- Viramune 2, record 2, English, Viramune
correct, trademark
- BI-RG-587 3, record 2, English, BI%2DRG%2D587
correct
Record 2, Textual support, English
Record number: 2, Textual support number: 1 DEF
An antiviral drug (a non nucleoside reverse transcriptase inhibitor) with anti-HIV activity. 4, record 2, English, - nevirapine
Record 2, French
Record 2, Domaine(s)
- Médicaments
Record 2, Main entry term, French
- névirapine
1, record 2, French, n%C3%A9virapine
correct
Record 2, Abbreviations, French
- NVP 2, record 2, French, NVP
correct
Record 2, Synonyms, French
- Viramune 3, record 2, French, Viramune
correct, trademark
- BI-RG-587 4, record 2, French, BI%2DRG%2D587
correct
Record 2, Textual support, French
Record number: 2, Textual support number: 1 DEF
Agent inhibiteur de la réplication ayant la propriété de bloquer soit la copie du matériel génétique du VIH (la première) soit la synthèse de la protéine-enveloppe. 1, record 2, French, - n%C3%A9virapine
Record 2, Spanish
Record 2, Campo(s) temático(s)
- Medicamentos
Record 2, Main entry term, Spanish
- nevirapine
1, record 2, Spanish, nevirapine
correct, masculine noun
Record 2, Abbreviations, Spanish
Record 2, Synonyms, Spanish
- Nevirapin 2, record 2, Spanish, Nevirapin
trademark, masculine noun
- Viramune 3, record 2, Spanish, Viramune
trademark, masculine noun
Record 2, Textual support, Spanish
Record number: 2, Textual support number: 1 DEF
Medicamento no nucleósido, inhibidor de la transcriptasa inversa. Se desconoce su interacción con los inhibidores de proteasa. 3, record 2, Spanish, - nevirapine
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