TERMIUM Plus®

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CALCISEPTINE [1 record]

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Record 1 2007-12-21

English

Subject field(s)
  • Toxicology
  • Cardiovascular System
DEF

[A] 60-amino acid [polypeptide], isolated from venom of the black mamba (Dendroaspis polylepis polylepis), that [blocks] voltage-dependent L-type Ca2+ channels.

French

Domaine(s)
  • Toxicologie
  • Système cardio-vasculaire
CONT

La calciseptine, isolée à partir du venin de Dendroaspis polylepis, interagit sélectivement avec le canal calcium de type L situé principalement au niveau des cellules cardiaques ventriculaires ou des cellules musculaires lisses aortiques. Sa fixation provoque le blocage de ce canal ionique et l'abolition du couplage excitation-contraction des cellules musculaires lisses et finalement à l'inhibition de la contraction cardiaque.

Spanish

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