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DYNAMIQUE PROTEINES [4 records]
Record 1 - internal organization data 2015-09-10
Record 1, English
Record 1, Subject field(s)
- Scientific Instruments
- Optics
- Biological Sciences
Record 1, Main entry term, English
- optical nanoscope
1, record 1, English, optical%20nanoscope
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- nanoscope 2, record 1, English, nanoscope
correct
- superresolution microscope 3, record 1, English, superresolution%20microscope
correct
- super resolution microscope 4, record 1, English, super%20resolution%20microscope
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
The imaging resolution of a conventional optical microscope is limited by diffraction to ~200 nm [nanometers] in the visible spectrum. Efforts to overcome such limits have stimulated the development of optical nanoscopes using metamaterial superlenses, nanoscale solid immersion lenses and molecular fluorescence microscopy. 1, record 1, English, - optical%20nanoscope
Record 1, French
Record 1, Domaine(s)
- Instruments scientifiques
- Optique
- Sciences biologiques
Record 1, Main entry term, French
- nanoscope optique
1, record 1, French, nanoscope%20optique
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- nanoscope 2, record 1, French, nanoscope
correct, masculine noun
- microscope de super-résolution 3, record 1, French, microscope%20de%20super%2Dr%C3%A9solution
correct, masculine noun
- microscope à super-résolution 4, record 1, French, microscope%20%C3%A0%20super%2Dr%C3%A9solution
correct, masculine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
[...] microscope optique qui permet de visualiser des objets à une résolution à l’échelle nanométrique. 3, record 1, French, - nanoscope%20optique
Record number: 1, Textual support number: 1 CONT
[Trois lauréats du Prix Nobel en chimie] ont chacun à leur manière contribué à accroître la résolution des microscopes optiques à fluorescence. Grâce à leurs travaux, il est désormais possible d’observer la matière vivante de manière dynamique à l'échelle des protéines, sans la détruire ni la figer. [...] le microscope est devenu un «nanoscope», en franchissant la barrière que l'on pensait infranchissable d’une résolution de 0, 2 micromètres. 4, record 1, French, - nanoscope%20optique
Record 1, Spanish
Record 1, Textual support, Spanish
Record 2 - internal organization data 2011-12-19
Record 2, English
Record 2, Subject field(s)
- Biological Sciences
Record 2, Main entry term, English
- leucine
1, record 2, English, leucine
correct
Record 2, Abbreviations, English
Record 2, Synonyms, English
- alpha-aminoisocaproic acid 2, record 2, English, alpha%2Daminoisocaproic%20acid
correct
- 2-amino-4-methylpentanoic acid 2, record 2, English, 2%2Damino%2D4%2Dmethylpentanoic%20acid
correct
- 2-amino-4-methylvaleric acid 3, record 2, English, 2%2Damino%2D4%2Dmethylvaleric%20acid
correct
Record 2, Textual support, English
Record number: 2, Textual support number: 1 CONT
Leucine may occur, with tyrosine, in urinary deposits, but is normally broken down into aceto-acetic acid in the metabolism. 4, record 2, English, - leucine
Record number: 2, Textual support number: 1 OBS
Leu and L are abbreviations used to denote the amino acid leucine in protein sequences and elsewhere. 2, record 2, English, - leucine
Record 2, Key term(s)
- L-leucine
- DL-leucine
Record 2, French
Record 2, Domaine(s)
- Sciences biologiques
Record 2, Main entry term, French
- leucine
1, record 2, French, leucine
correct, feminine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
- acide alpha-amino isocaproïque 2, record 2, French, acide%20alpha%2Damino%20isocapro%C3%AFque
correct, masculine noun
- acide alpha-amino-isocaproïque 2, record 2, French, acide%20alpha%2Damino%2Disocapro%C3%AFque
correct, masculine noun
- acide amino-2-méthyl-4-valérique 2, record 2, French, acide%20amino%2D2%2Dm%C3%A9thyl%2D4%2Dval%C3%A9rique
correct, masculine noun
- acide amino-2 méthyl-4 pentanoïque 3, record 2, French, acide%20amino%2D2%20m%C3%A9thyl%2D4%20pentano%C3%AFque
correct, masculine noun
Record 2, Textual support, French
Record number: 2, Textual support number: 1 DEF
Acide aminé, constituant des protéines, indispensable au métabolisme de l’organisme humain. Il se trouve en abondance dans tous les animaux et les végétaux. C’est l’homologue supérieure de la valine. 2, record 2, French, - leucine
Record number: 2, Textual support number: 1 CONT
On appelle «état dynamique des protéines» ce métabolisme protéique permanent, caractérisé d’un côté par une dégradation continue et de l'autre par une biosynthèse permanente des protéines à partir du «pool métabolique des aminoacides»(constitué par les aminoacides d’origine alimentaire et ceux libérés par hydrolyse des protéines tissulaires). Si l'aminoacide-marqué par l'isotope15N-que l'on administre à l'animal est la leucine par exemple, on constate que dans les protéines hépatiques c'est la leucine qui a le plus fort pourcentage de15N(une partie de la leucine marquée administrée a donc été incorporée telle quelle), mais d’autres aminoacides sont «également marqués. » 4, record 2, French, - leucine
Record number: 2, Textual support number: 1 OBS
Leu et L sont des abréviations de leucine. 2, record 2, French, - leucine
Record 2, Spanish
Record 2, Campo(s) temático(s)
- Ciencias biológicas
Record 2, Main entry term, Spanish
- leucina
1, record 2, Spanish, leucina
feminine noun
Record 2, Abbreviations, Spanish
Record 2, Synonyms, Spanish
Record 2, Textual support, Spanish
Record 3 - internal organization data 2010-05-21
Record 3, English
Record 3, Subject field(s)
- Biological Sciences
Record 3, Main entry term, English
- protein dynamics
1, record 3, English, protein%20dynamics
correct
Record 3, Abbreviations, English
Record 3, Synonyms, English
Record 3, Textual support, English
Record number: 3, Textual support number: 1 CONT
Dynamics is a term that covers all of the intramolecular motions of proteins. These may be the motions of individual atoms, groups of atoms, or whole sections of the protein. These motions can be divided into three broad categories, characterized by the extent and time scale of the motion and by the method that is used to study it; ... 1) atomic fluctuations, ... 2) collective motions, ... 3) triggered conformational changes.... As the predictive abilities increase, the study of protein dynamics will have application to practical problems in endeavors such as genetic engineering or the effort to modify an enzyme to better serve an industrial process. 2, record 3, English, - protein%20dynamics
Record 3, French
Record 3, Domaine(s)
- Sciences biologiques
Record 3, Main entry term, French
- dynamique des protéines
1, record 3, French, dynamique%20des%20prot%C3%A9ines
correct, feminine noun
Record 3, Abbreviations, French
Record 3, Synonyms, French
Record 3, Textual support, French
Record number: 3, Textual support number: 1 CONT
La dynamique des protéines [...] étudie [...] les mouvements moléculaires [...] des protéines. [...] Comme les atomes d’une protéine globulaire sont proches les uns des autres, les mouvements de chaque atome sont limités; en revanche ces petits mouvements locaux produisent parfois des déformations plus globales, à plus grande échelle, de la protéine. 2, record 3, French, - dynamique%20des%20prot%C3%A9ines
Record number: 3, Textual support number: 1 OBS
Sur de courts intervalles de temps (quelques dixièmes de picoseconde), les mouvements les plus importants sont des mouvements locaux des peptides ou des chaînes latérales, qui tournent de 20 à 60 degrés autour des liaisons covalentes les reliant au reste de la chaîne principale. [...] Sur des intervalles de temps plus longs, de l’ordre de plusieurs picosecondes, les [...] déformations des protéines sont alors plus collectives que les oscillations locales : ce sont par exemple des déplacements simultanés de quelques acides aminés adjacents, ou des déformations de la molécule tout entière. 1, record 3, French, - dynamique%20des%20prot%C3%A9ines
Record 3, Spanish
Record 3, Textual support, Spanish
Record 4 - internal organization data 2010-03-22
Record 4, English
Record 4, Subject field(s)
- Biochemistry
- Molecular Biology
Record 4, Main entry term, English
- cofilin
1, record 4, English, cofilin
correct
Record 4, Abbreviations, English
Record 4, Synonyms, English
Record 4, Textual support, English
Record number: 4, Textual support number: 1 DEF
A small... actin- and phosphatidylinositol-binding protein mediating the rapid turnover of actin in the cytoskeleton. 1, record 4, English, - cofilin
Record 4, French
Record 4, Domaine(s)
- Biochimie
- Biologie moléculaire
Record 4, Main entry term, French
- cofiline
1, record 4, French, cofiline
correct, feminine noun
Record 4, Abbreviations, French
Record 4, Synonyms, French
Record 4, Textual support, French
Record number: 4, Textual support number: 1 CONT
Les protéines de liaison à l'actine de la famille cofiline/ADF(actin depolymerizing factor) contrôlent la dynamique du cytosquelette d’actine par leur activité de coupure et de dépolymérisation des filaments d’actine. En revanche, leur rôle dans la migration et l'invasion des cellules tumorales est encore mal connu. 1, record 4, French, - cofiline
Record 4, Spanish
Record 4, Textual support, Spanish
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