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GABA [9 records]
Record 1 - internal organization data 2025-10-16
Record 1, English
Record 1, Subject field(s)
- Animal Diseases
- Horse Husbandry
Record 1, Main entry term, English
- tetanus
1, record 1, English, tetanus
correct, noun
Record 1, Abbreviations, English
Record 1, Synonyms, English
- lockjaw 2, record 1, English, lockjaw
correct, noun
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
Tetanus (lockjaw) is caused by neurotoxins produced by the bacteria Clostridium tetani, particularly in deep or closed wounds, such as puncture wounds, but may occur, due to intestinal infections. This highly fatal disease is a constant threat for all horses as the bacteria are widely distributed in soil and manure. ... Clinical signs of tetanus in affected horses begin following an incubation period of 3 days to several weeks, but usually 1 to 2 weeks. Muscle spasms and stiff paralysis progressing from the head to the neck, front, and then hind legs occurs. ... The horse may be unable to swallow, resulting in saliva dripping from the mouth and regurgitation of ingested food and water through the nose. Convulsions, muscle rigidity, sweating, and fever may follow. 3, record 1, English, - tetanus
Record 1, Key term(s)
- lock-jaw
- lock jaw
Record 1, French
Record 1, Domaine(s)
- Maladies des animaux
- Élevage des chevaux
Record 1, Main entry term, French
- tétanos
1, record 1, French, t%C3%A9tanos
correct, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- mal de cerf 2, record 1, French, mal%20de%20cerf
correct, masculine noun, obsolete
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
Le tétanos est causé par des neurotoxines produites par Clostridium tetani, une bactérie présente dans le sol et les matières fécales de certains mammifères. À la faveur d’une brèche cutanée(plaie, abcès de pieds, cordon ombilical), C. tetani prolifère et produit la tétanolysine(qui lyse les tissus environnants et crée un milieu favorable à l'infection) et la tétanospasmine. La tétanospasmine remonte le long de l'axone des motoneurones et bloque la libération du neurotransmetteur GABA [acide gamma-aminobutyrique] par les interneurones inhibiteurs, ce qui lève l'inhibition de la contraction musculaire. Ceci entraîne une tétanie spastique [...] Les chevaux sont parmi les mammifères les plus sensibles au tétanos. Les spasmes commencent généralement au niveau de la tête et du cou(hyperextension de l'encolure, procidence de la 3e paupière, lèvres et nez retroussés), puis évoluent en une raideur généralisée, une incapacité à se nourrir, un décubitus et la mort par arrêt respiratoire. 3, record 1, French, - t%C3%A9tanos
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Enfermedades de los animales
- Cría de ganado caballar
Record 1, Main entry term, Spanish
- tétanos
1, record 1, Spanish, t%C3%A9tanos
correct, masculine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record 2 - internal organization data 2025-05-27
Record 2, English
Record 2, Subject field(s)
- Medication
Record 2, Main entry term, English
- benzodiazepine
1, record 2, English, benzodiazepine
correct, noun
Record 2, Abbreviations, English
- BZD 2, record 2, English, BZD
correct, noun
Record 2, Synonyms, English
- benzo 3, record 2, English, benzo
correct, noun, familiar
Record 2, Textual support, English
Record number: 2, Textual support number: 1 DEF
Any of a group of compounds having a common molecular structure and acting similarly as depressants in the central nervous system, their actions including antianxiety, sedative, hypnotic, amnestic, anticonvulsant, and muscle relaxing effects. 4, record 2, English, - benzodiazepine
Record number: 2, Textual support number: 1 CONT
Benzodiazepines (BZD) are drugs marketed since the 1960s that act on the central nervous system through GABA [gamma-aminobutyric acid] receptors. 5, record 2, English, - benzodiazepine
Record 2, French
Record 2, Domaine(s)
- Médicaments
Record 2, Main entry term, French
- benzodiazépine
1, record 2, French, benzodiaz%C3%A9pine
correct, feminine noun
Record 2, Abbreviations, French
- BZD 2, record 2, French, BZD
correct, feminine noun
Record 2, Synonyms, French
- benzo 3, record 2, French, benzo
correct, feminine noun, familiar
Record 2, Textual support, French
Record number: 2, Textual support number: 1 CONT
Les benzodiazépines agissent, au niveau du système nerveux central, sur des récepteurs spécifiques étroitement liés aux récepteurs du GABA(acide gamma-aminobutyrique) et au canal du chlore. 4, record 2, French, - benzodiaz%C3%A9pine
Record number: 2, Textual support number: 1 OBS
[...] les réponses de l’organisme aux benzodiazépines correspondent à une diminution de l’activité neuronale : diminution de l’anxiété (effet anxiolytique), diminution de la vigilance (effet sédatif et hypnotique), diminution d’origine centrale du tonus musculaire (effet myorelaxant, anticonvulsivant et antiépileptogène). Chaque benzodiazépine induit l’ensemble de ces réponses, mais l’une ou l’autre peut être plus marquée. 5, record 2, French, - benzodiaz%C3%A9pine
Record 2, Spanish
Record 2, Campo(s) temático(s)
- Medicamentos
Record 2, Main entry term, Spanish
- benzodiacepina
1, record 2, Spanish, benzodiacepina
correct, feminine noun
Record 2, Abbreviations, Spanish
Record 2, Synonyms, Spanish
Record 2, Textual support, Spanish
Record number: 2, Textual support number: 1 CONT
Las benzodiacepinas pertenecen al grupo de medicamentos llamados depresores del sistema nervioso central, (medicamentos que frenan el sistema nervioso). [...] Muchas de las benzodiacepinas se utilizan en el tratamiento de otras condiciones, también. Diazepam se utiliza para ayudar a relajar los músculos o aliviar los espasmos musculares. 2, record 2, Spanish, - benzodiacepina
Record 2, Key term(s)
- benzodiazepina
Record 3 - internal organization data 2013-10-10
Record 3, English
Record 3, Subject field(s)
- Nervous System
Record 3, Main entry term, English
- gamma-aminobutyric acid receptor
1, record 3, English, gamma%2Daminobutyric%20acid%20receptor
correct, see observation
Record 3, Abbreviations, English
Record 3, Synonyms, English
- GABA receptor 2, record 3, English, GABA%20receptor
correct
Record 3, Textual support, English
Record number: 3, Textual support number: 1 CONT
GABA (gamma-aminobutyric acid) receptors are divided into three classes: A, B and C. The GABA-A receptor is very complex, composed of five subunits, and containing a chloride channel, estimated to be about 5 nm in diameter. 2, record 3, English, - gamma%2Daminobutyric%20acid%20receptor
Record number: 3, Textual support number: 1 OBS
gamma: This word must be italicized or replaced by the corresponding Greek letter. 3, record 3, English, - gamma%2Daminobutyric%20acid%20receptor
Record 3, Key term(s)
- γ-aminobutyric acid receptor
Record 3, French
Record 3, Domaine(s)
- Système nerveux
Record 3, Main entry term, French
- récepteur de l’acide gamma-aminobutyrique
1, record 3, French, r%C3%A9cepteur%20de%20l%26rsquo%3Bacide%20gamma%2Daminobutyrique
correct, see observation, masculine noun
Record 3, Abbreviations, French
Record 3, Synonyms, French
- récepteur de GABA 2, record 3, French, r%C3%A9cepteur%20de%20GABA
correct, masculine noun
Record 3, Textual support, French
Record number: 3, Textual support number: 1 CONT
Le traducteur final des états d’anxiété, d’angoisse et de dépression est certainement le complexe amygdalien. Cette structure est particulièrement riche en récepteurs de l'acide gamma-aminobutyrique(GABA), le neurotransmetteur chargé de l'inhibition de pratiquement tout le cerveau. 2, record 3, French, - r%C3%A9cepteur%20de%20l%26rsquo%3Bacide%20gamma%2Daminobutyrique
Record number: 3, Textual support number: 1 OBS
gamma : Ce mot s’écrit en italique ou doit être remplacé par la lettre grecque correspondante. 3, record 3, French, - r%C3%A9cepteur%20de%20l%26rsquo%3Bacide%20gamma%2Daminobutyrique
Record 3, Key term(s)
- récepteur de l’acide γ-aminobutyrique
Record 3, Spanish
Record 3, Textual support, Spanish
Record 4 - internal organization data 2013-08-28
Record 4, English
Record 4, Subject field(s)
- Chemical Elements and Compounds
- Biochemistry
Universal entry(ies) Record 4
Record 4, Main entry term, English
- 4-aminobutanoic acid
1, record 4, English, 4%2Daminobutanoic%20acid
correct, see observation
Record 4, Abbreviations, English
Record 4, Synonyms, English
- 4-aminobutyric acid 1, record 4, English, 4%2Daminobutyric%20acid
- gamma-aminobutyric acid 2, record 4, English, gamma%2Daminobutyric%20acid
see observation
- piperidic acid 4, record 4, English, piperidic%20acid
- piperidinic acid 5, record 4, English, piperidinic%20acid
Record 4, Textual support, English
Record number: 4, Textual support number: 1 DEF
A chemical compound which appears under the form of crystals which are either leaflets or needles, with a melting point of 202°C, and which is thought to be a central nervous system postsynaptic inhibitory transmitter. 6, record 4, English, - 4%2Daminobutanoic%20acid
Record number: 4, Textual support number: 1 OBS
4-aminobutanoic acid: form recommended by the IUPAC (International Union of Pure and Applied Chemistry). 7, record 4, English, - 4%2Daminobutanoic%20acid
Record number: 4, Textual support number: 2 OBS
gamma: This word must be italicized or replaced by the corresponding Greek letter. 6, record 4, English, - 4%2Daminobutanoic%20acid
Record number: 4, Textual support number: 3 OBS
Also known under the following commercial designations: DF 478; Gamarex; Gammalon. 6, record 4, English, - 4%2Daminobutanoic%20acid
Record number: 4, Textual support number: 4 OBS
Chemical formula: C4H9NO2 or H9O2C4N 6, record 4, English, - 4%2Daminobutanoic%20acid
Record 4, French
Record 4, Domaine(s)
- Éléments et composés chimiques
- Biochimie
Entrée(s) universelle(s) Record 4
Record 4, Main entry term, French
- acide 4-aminobutanoïque
1, record 4, French, acide%204%2Daminobutano%C3%AFque
correct, see observation, masculine noun
Record 4, Abbreviations, French
Record 4, Synonyms, French
- acide gamma-aminobutyrique 2, record 4, French, acide%20gamma%2Daminobutyrique
see observation, masculine noun
- GABA 3, record 4, French, GABA
masculine noun
- GABA 3, record 4, French, GABA
Record 4, Textual support, French
Record number: 4, Textual support number: 1 DEF
Acide aminé présent dans le système nerveux central des vertèbres, où il exerce le rôle de neuromédiateur inhibiteur. 4, record 4, French, - acide%204%2Daminobutano%C3%AFque
Record number: 4, Textual support number: 1 OBS
La fonction du GABA est la diminution de l'activité, laquelle est réalisée par hyperpolarisation de la membrane postsynaptique. 4, record 4, French, - acide%204%2Daminobutano%C3%AFque
Record number: 4, Textual support number: 2 OBS
acide 4-aminobutanoïque : forme recommandée par l’UICPA (Union internationale de chimie pure et appliquée). 1, record 4, French, - acide%204%2Daminobutano%C3%AFque
Record number: 4, Textual support number: 3 OBS
gamma : Ce mot s’écrit en italique ou doit être remplacé par la lettre grecque correspondante. 5, record 4, French, - acide%204%2Daminobutano%C3%AFque
Record number: 4, Textual support number: 4 OBS
Formule chimique : C4H9NO2 ou H9O2C4N 5, record 4, French, - acide%204%2Daminobutano%C3%AFque
Record 4, Spanish
Record 4, Campo(s) temático(s)
- Elementos y compuestos químicos
- Bioquímica
Entrada(s) universal(es) Record 4
Record 4, Main entry term, Spanish
- ácido gamma-aminobutírico
1, record 4, Spanish, %C3%A1cido%20gamma%2Daminobut%C3%ADrico
correct, masculine noun
Record 4, Abbreviations, Spanish
- GABA 1, record 4, Spanish, GABA
correct
Record 4, Synonyms, Spanish
Record 4, Textual support, Spanish
Record number: 4, Textual support number: 1 OBS
Fórmula química: C4H9NO2 o H9O2C4N 2, record 4, Spanish, - %C3%A1cido%20gamma%2Daminobut%C3%ADrico
Record 5 - internal organization data 2011-10-31
Record 5, English
Record 5, Subject field(s)
- Biochemistry
- Genetics
Record 5, Main entry term, English
- tetanus neurotoxin
1, record 5, English, tetanus%20neurotoxin
correct
Record 5, Abbreviations, English
- TeNT 2, record 5, English, TeNT
correct
Record 5, Synonyms, English
Record 5, Textual support, English
Record number: 5, Textual support number: 1 CONT
Tetanus (TeNT) and botulinum neurotoxins (BONT, seven different types A-G) are responsible of the neuroparalytic syndromes of tetanus and botulism, respectively. They consist of a heavy chain involved in neurospecific binding and cell penetration of the light chain, which is responsible for the blockade of neurotransmitter release. 1, record 5, English, - tetanus%20neurotoxin
Record 5, French
Record 5, Domaine(s)
- Biochimie
- Génétique
Record 5, Main entry term, French
- neurotoxine tétanique
1, record 5, French, neurotoxine%20t%C3%A9tanique
correct, feminine noun
Record 5, Abbreviations, French
- TeNT 2, record 5, French, TeNT
correct, feminine noun
Record 5, Synonyms, French
Record 5, Textual support, French
Record number: 5, Textual support number: 1 CONT
Les neurotoxines tétaniques(TeTN) et botuliques(BoNT) sont responsables de deux maladies sévères : le tétanos et le botulisme. Le TnNT bloque la libération de GABA et de glycine dans le système nerveux central alors que les BoNT agissent en périphérie en inhibant la libération d’acétylcholine. 1, record 5, French, - neurotoxine%20t%C3%A9tanique
Record 5, Spanish
Record 5, Campo(s) temático(s)
- Bioquímica
- Genética
Record 5, Main entry term, Spanish
- neurotoxina tetánica
1, record 5, Spanish, neurotoxina%20tet%C3%A1nica
correct, feminine noun
Record 5, Abbreviations, Spanish
Record 5, Synonyms, Spanish
Record 5, Textual support, Spanish
Record number: 5, Textual support number: 1 CONT
La causa del tétanos es la neurotoxina tetánica producida por el Clostridium tetani. 1, record 5, Spanish, - neurotoxina%20tet%C3%A1nica
Record 6 - internal organization data 2011-10-31
Record 6, English
Record 6, Subject field(s)
- Biochemistry
- Genetics
Record 6, Main entry term, English
- Botulinum neurotoxin
1, record 6, English, Botulinum%20neurotoxin
correct
Record 6, Abbreviations, English
- BoNT 2, record 6, English, BoNT
correct
Record 6, Synonyms, English
Record 6, Textual support, English
Record number: 6, Textual support number: 1 OBS
With the increasing use of Botulinum toxin in the treatment of various neuromuscular disorders, it is very important that all who are involved be kept up with the latest developments and indications for the use of the toxin. The current literature reflects the potential uses of the toxin but at the same time discrepancies in the dosage of the toxin, and measurement of toxin activity are arising. In addition, basic scientists interested in the toxin for its elegant role as a molecular tool. 3, record 6, English, - Botulinum%20neurotoxin
Record number: 6, Textual support number: 2 OBS
This article appeared in the following journal. Toxicon, Vol. 33, No. 2, pp. 21. 3, record 6, English, - Botulinum%20neurotoxin
Record 6, French
Record 6, Domaine(s)
- Biochimie
- Génétique
Record 6, Main entry term, French
- neurotoxine botulique
1, record 6, French, neurotoxine%20botulique
correct, feminine noun
Record 6, Abbreviations, French
- BoNT 2, record 6, French, BoNT
correct, feminine noun
Record 6, Synonyms, French
Record 6, Textual support, French
Record number: 6, Textual support number: 1 CONT
Les neurotoxines tétaniques(TeTN) et botuliques(BoNT) sont responsables de deux maladies sévères : le tétanos et le botulisme. Le TnNT bloque la libération de GABA [acide 4-aminobutanoïque] et de glycine dans le système nerveux central alors que les BoNT agissent en périphérie en inhibant la libération d’acétylcholine. 1, record 6, French, - neurotoxine%20botulique
Record 6, Spanish
Record 6, Campo(s) temático(s)
- Bioquímica
- Genética
Record 6, Main entry term, Spanish
- neurotoxina botulínica
1, record 6, Spanish, neurotoxina%20botul%C3%ADnica
correct, feminine noun
Record 6, Abbreviations, Spanish
- NTBo 1, record 6, Spanish, NTBo
correct, feminine noun
Record 6, Synonyms, Spanish
- neurotoxina del botulismo 2, record 6, Spanish, neurotoxina%20del%20botulismo
correct, feminine noun
Record 6, Textual support, Spanish
Record number: 6, Textual support number: 1 DEF
[Neurotoxina] producida por la bacteria Clostridium botulinum como un complejo de proteínas que contiene la fracción neurotóxica asociada con componentes no tóxicos. 1, record 6, Spanish, - neurotoxina%20botul%C3%ADnica
Record number: 6, Textual support number: 1 CONT
La NTBo se sintetiza como una cadena polipeptídica simple [...]. Existen siete serotipos de la NTBo (A, B, C1, D, E, F y G); todos ellos inhiben la liberación de acetilcolina aunque difieren considerablemente con respecto a sus proteínas diana intracelulares, las características de sus efectos y sus potencias. 1, record 6, Spanish, - neurotoxina%20botul%C3%ADnica
Record number: 6, Textual support number: 2 CONT
La neurotoxina del tétanos [...] actúa principalmente en el sistema nervioso central, mientras que la neurotoxina del botulismo [...] actúa en la unión neuromuscular inhibiendo la liberación de acetilcolina del axón de la neurona afectada hacia la sinapsis, dando como resultado una parálisis fláccida localizada. 2, record 6, Spanish, - neurotoxina%20botul%C3%ADnica
Record 7 - internal organization data 2011-02-25
Record 7, English
Record 7, Subject field(s)
- Chemical Elements and Compounds
- Medication
Universal entry(ies) Record 7
Record 7, Main entry term, English
- baclofen
1, record 7, English, baclofen
correct
Record 7, Abbreviations, English
Record 7, Synonyms, English
- 4-amino-3-(4-chlorophenyl)butanoic acid 2, record 7, English, 4%2Damino%2D3%2D%284%2Dchlorophenyl%29butanoic%20acid
correct, see observation
- 4-amino-3-(p-chlorophenyl)butyric acid 3, record 7, English, 4%2Damino%2D3%2D%28p%2Dchlorophenyl%29butyric%20acid
correct
Record 7, Textual support, English
Record number: 7, Textual support number: 1 DEF
A muscle relaxant ... which is an analogue of gamma-aminobutyric acid ... 4, record 7, English, - baclofen
Record number: 7, Textual support number: 1 OBS
4-amino-3-(4-chlorophenyl)butanoic acid: formrecommended by the IUPAC (International Union of Pure and Applied Chemistry) for the systematic name corresponding to the CAS number indicated on the present record. 5, record 7, English, - baclofen
Record number: 7, Textual support number: 2 OBS
Chemical formula: C10H12ClNO2 5, record 7, English, - baclofen
Record 7, French
Record 7, Domaine(s)
- Éléments et composés chimiques
- Médicaments
Entrée(s) universelle(s) Record 7
Record 7, Main entry term, French
- baclofène
1, record 7, French, baclof%C3%A8ne
correct, masculine noun
Record 7, Abbreviations, French
Record 7, Synonyms, French
Record 7, Textual support, French
Record number: 7, Textual support number: 1 CONT
Le baclofène, médicament antispasmique de référence, est un agoniste spécifique des récepteurs GABA B, très nombreux dans les couches superficielles de la moelle épinière. 2, record 7, French, - baclof%C3%A8ne
Record number: 7, Textual support number: 1 OBS
Formule chimique : C10H12ClNO2 3, record 7, French, - baclof%C3%A8ne
Record 7, Spanish
Record 7, Campo(s) temático(s)
- Elementos y compuestos químicos
- Medicamentos
Entrada(s) universal(es) Record 7
Record 7, Main entry term, Spanish
- baclofeno
1, record 7, Spanish, baclofeno
masculine noun
Record 7, Abbreviations, Spanish
Record 7, Synonyms, Spanish
Record 7, Textual support, Spanish
Record number: 7, Textual support number: 1 OBS
Fórmula química: C10H12ClNO2 2, record 7, Spanish, - baclofeno
Record 8 - internal organization data 1995-07-21
Record 8, English
Record 8, Subject field(s)
- Clothing
Record 8, Main entry term, English
- jacket 1, record 8, English, jacket
Record 8, Abbreviations, English
Record 8, Synonyms, English
Record 8, Textual support, English
Record 8, French
Record 8, Domaine(s)
- Vêtements
Record 8, Main entry term, French
- caban
1, record 8, French, caban
masculine noun
Record 8, Abbreviations, French
Record 8, Synonyms, French
Record 8, Textual support, French
Record number: 8, Textual support number: 1 DEF
Vêtement de haut du corps. 1, record 8, French, - caban
Record number: 8, Textual support number: 1 CONT
Capeler son caban. 1, record 8, French, - caban
Record number: 8, Textual support number: 1 OBS
De l'arabe, gaba, manteau. 1, record 8, French, - caban
Record 8, Spanish
Record 8, Campo(s) temático(s)
- Prendas de vestir
Record 8, Main entry term, Spanish
- chaquetón
1, record 8, Spanish, chaquet%C3%B3n
masculine noun
Record 8, Abbreviations, Spanish
Record 8, Synonyms, Spanish
Record 8, Textual support, Spanish
Record 9 - internal organization data 1986-01-17
Record 9, English
Record 9, Subject field(s)
- Medication
Record 9, Main entry term, English
- GABAergic inhibition 1, record 9, English, GABAergic%20inhibition
Record 9, Abbreviations, English
Record 9, Synonyms, English
Record 9, French
Record 9, Domaine(s)
- Médicaments
Record 9, Main entry term, French
- inhibition par la GABA 1, record 9, French, inhibition%20par%20la%20GABA
Record 9, Abbreviations, French
Record 9, Synonyms, French
Record 9, Textual support, French
Record 9, Spanish
Record 9, Textual support, Spanish
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