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MODULATION ALLOSTERIQUE [2 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2012-07-18

English

Subject field(s)
  • Biochemistry
  • Molecular Biology
DEF

The regulation of enzyme activity via cooperative protein-ligand interactions and via effector ligands which either switch on or off individual enzymes.

French

Domaine(s)
  • Biochimie
  • Biologie moléculaire
DEF

Régulation où la fonction catalytique des enzymes est physiologiquement réglée par l’intermédiaire de changements de conformation de la protéine, provoqués par l’interaction avec elle des molécules de substrats, d’une part, et de molécules dites allostériques, d’autre part, stériquement différentes du substrat.

OBS

Ces dernières molécules s’associent à un site dit allostérique.

Spanish

Campo(s) temático(s)
  • Bioquímica
  • Biología molecular
Save record 1

Record 2 2011-05-16

English

Subject field(s)
  • Biological Sciences
DEF

Type of allosteric enzyme in which the substrate serves as the allosteric effector. These homotropic effects appear always to be cooperative (i.e. the binding of one ligand molecule to the protein enhances the binding of further ligand molecules) and are illustrated by the classical example for the haemoglobin - oxygen system. Other examples include enzymes possessing more than one substrate binding site.

CONT

Homotropic enzymes contain two or more binding sites for the substrate; modulation of these enzymes depends on how many of the substrate sites are occupied.

French

Domaine(s)
  • Sciences biologiques
DEF

Enzyme allostérique pour laquelle le substrat sert de molécule modulatrice. Ces enzymes contiennent au moins deux sites d’attachement pour le substrat, leur modulation dépendant du nombre de sites de substrats occupés.

OBS

Un grand nombre (sinon la plupart) des enzymes allostériques sont d’un type mixte homotrope-hétérotrope où le substrat et un ou plusieurs autres métabolites peuvent agir comme modulateurs.

Spanish

Save record 2

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