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ARNI [2 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2026-03-20

English

Subject field(s)
  • Medication
  • Cardiovascular System
CONT

ARNI, or an angiotensin receptor/neprilysin inhibitor, is made up of two drugs put together to treat heart failure. It contains an ARB (angiotensin II receptor blocker) and a neprilysin inhibitor.

CONT

Angiotensin II receptor–neprilysin inhibitors. Sacubitril-valsartan is a fixed dose combination of the angiotensin II receptor blocker valsartan and the neprilysin inhibitor sacubitril. ... Sacubitril/valsartan is a combination product. Sacubritil acts as a neprilysin inhibitor and works by blocking the action of neprilysin, inhibiting the breakdown of natriuretic peptides. This results in increased diuresis, vasodilation, reduction in blood pressure and work on the heart. Valsartan is an angiotensin receptor blocker and inhibits the RAAS [renin-angiotensin aldosterone system] ... to reduce the maladaptive response to cardiac failure. Neprilysin breaks down angiotensin II, so sacubitril given alone would result in an accumulation of angiotensin II. For this reason, it must be combined with an angiotensin receptor blocker to block the effect of excess angiotensin II.

Key term(s)
  • angiotensin 2 receptor and neprilysin inhibitor
  • angiotensin 2 receptor–neprilysin inhibitor
  • angiotensin 2 receptor/neprilysin inhibitor

French

Domaine(s)
  • Médicaments
  • Système cardio-vasculaire
OBS

Médicament composé de deux agents actifs qui est employé pour traiter l'insuffisance cardiaque.

Key term(s)
  • inhibiteur de la néprilysine/antagoniste des récepteurs de l'angiotensine 2

Spanish

Save record 1

Record 2 2026-01-07

English

Subject field(s)
  • Genetics
DEF

A posttranscriptional genetic mechanism of eukaryotes that suppresses gene expression and in which double-stranded RNA [ribonucleic acid] cleaved into small fragments initiates the degradation of a complementary messenger RNA sequence.

French

Domaine(s)
  • Génétique
CONT

L'interférence d'ARN [acide ribonucléique] est un mécanisme de régulation post-transcriptionnel physiologique très conservé dans l'évolution, conduisant à l'inhibition de l'expression génique. L'interférence est due au clivage des ARN double brin dans la cellule par des petites molécules d'ARN [...] qui ciblent des séquences complémentaires et entraînent la destruction de l'ARN sous l'effet d'un complexe comprenant une ribonucléase.

Spanish

Save record 2

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