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GENE NRAMP1 [1 record]

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Record 1 2010-04-20

English

Subject field(s)
  • Genetics
CONT

The Bcg/Ity/Lsh locus is a major gene controlling early phases of infection with intracellular parasites in mice. Natural resistance associated macrophage protein 1 (Nramp1) has been shown to be the Bcg gene in mice. Analysis of a bovine cDNA homolog of murine Nramp1, designated as bovine NRAMP1, predicted a 548-amino-acid protein with hydrophobic domains, an amino-terminal SH3-binding domain, and a conserved consensus transport motif. Northern blotting indicated that bovine NRAMP1 was expressed primarily in macrophages and tissues of the recticuloendothelial system.

French

Domaine(s)
  • Génétique
CONT

Le gène NRAMP1 (natural resistance associated macrophage protein 1) code pour une protéine intégrale des cellules phagocytaires professionnelles, macrophages et granulocytes, localisée dans la membrane de leurs phagosomes. Il participe à la résistance naturelle aux infections: en son absence, ou lorsqu'il est muté, la croissance des parasites intracellulaires, Mycobacterium, leishamania, Salmonelles [...] n'est plus contrôlée.

Spanish

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