TERMIUM Plus®
The Government of Canada’s terminology and linguistic data bank.
GENES SUICIDES [1 record]
Record 1 - internal organization data 2005-02-18
Record 1, English
Record 1, Subject field(s)
- Human Diseases - Various
Record 1, Main entry term, English
- suicide gene
1, record 1, English, suicide%20gene
correct, see observation
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
A gene which is not toxic itself but which is used to kill cells. A group of these genes, which are inserted into a cell, would program the cell to react, when treated with a drug, to generate its own toxin and thereby killing itself. 2, record 1, English, - suicide%20gene
Record number: 1, Textual support number: 1 CONT
In another approach, researchers inject cancer cells with genes that can be used to destroy the cells. In this technique, "suicide genes" are introduced into cancer cells. Later, a pro-drug (an inactive form of a toxic drug) is given to the patient. The pro-drug is activated in cancer cells containing these "suicide genes," which leads to the destruction of those cancer cells. 3, record 1, English, - suicide%20gene
Record number: 1, Textual support number: 1 OBS
suicide gene: This expression is often used in its plural form "suicide genes". 2, record 1, English, - suicide%20gene
Record 1, Key term(s)
- suicide genes
Record 1, French
Record 1, Domaine(s)
- Maladies humaines diverses
Record 1, Main entry term, French
- gène suicide
1, record 1, French, g%C3%A8ne%20suicide
correct, see observation, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- gène cytotoxique 2, record 1, French, g%C3%A8ne%20cytotoxique
correct, see observation, masculine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
Les gènes cytotoxiques, aussi appelés «gènes suicides», codent pour des enzymes qui convertissent un agent chimiothérapeutique non toxique (la «prodrogue») en une molécule toxique. 2, record 1, French, - g%C3%A8ne%20suicide
Record number: 1, Textual support number: 2 CONT
L'utilisation de gènes suicides vise à détruire les cellules tumorales par l'expression au sein de ces cellules d'une protéine toxique. La stratégie utilisée consiste à faire exprimer par les cellules tumorales une enzyme qui métabolise localement une prodrogue en une molécule très toxique pour la cellule. 3, record 1, French, - g%C3%A8ne%20suicide
Record number: 1, Textual support number: 1 OBS
Ces expressions sont souvent utilisées au pluriel. 4, record 1, French, - g%C3%A8ne%20suicide
Record 1, Key term(s)
- gènes suicides
- gènes cytotoxiques
Record 1, Spanish
Record 1, Textual support, Spanish
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