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NOYAU BASAL MEYNERT [1 record]

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Record 1 2010-04-20

English

Subject field(s)
  • Morphology and General Physiology
CONT

Animals in this group received implantations of their own genetically modified fibroblasts (i.e. autografts) into the Nucleus Basalis of Meynert (NBM). The NBM was chosen as an injection site because it contains NGF-responsive cholinergic cell bodies (Mandel et al. 1989), permitting assessment of responses of intact cholinergic neurites to NGF-secreting of control cells.

French

Domaine(s)
  • Morphologie et physiologie générale
CONT

Le noyau basal de Meynart, siège de dégénérescence importante dans les démences séniles de type Alzheimer, est source principale de l'innervation cholinergique du néocortex. La stimulation du noyau basal magnocellulaire (NBM), son équivalent chez le rat, induit de fortes augmentations du débit sanguin cortical sous-tendues par des mécanismes cholinergiques et nitrergiques.

Spanish

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