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RELATION CLE SERRURE [2 records]
Record 1 - internal organization data 2010-09-15
Record 1, English
Record 1, Subject field(s)
- Biological Sciences
Record 1, Main entry term, English
- lock-and-key relationship
1, record 1, English, lock%2Dand%2Dkey%20relationship
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
Model, explaining the great specificity of enzymes for their substrates, in which the enzyme has an active site complementary to the shape of the substrate. If the substrate has a different shape, it not bind. 2, record 1, English, - lock%2Dand%2Dkey%20relationship
Record number: 1, Textual support number: 1 CONT
One of the first important studies on the specificity of enzymes was carried out by Emil Fischer, who found that enzymes capable of hydrolyzing glycosides can distinguish between their stereoisomeric forms. In 1894 this observation led him to enunciate the principle that the substrate molecule fits the active site of the enzyme in a ... lock-and-key relationship.... Nowadays, the modified concept of transition state stabilization is gaining favor. According to this idea, it is not that the substrate is distorted but rather that the transition state makes better contacts with the enzyme than the substrate does, so that the full binding energy is not realized until the transition state is reached. Nevertheless, we shall use the term strain to cover the general situation on enzyme-transition state complementary. 3, record 1, English, - lock%2Dand%2Dkey%20relationship
Record 1, French
Record 1, Domaine(s)
- Sciences biologiques
Record 1, Main entry term, French
- modèle clef-serrure
1, record 1, French, mod%C3%A8le%20clef%2Dserrure
correct, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- relation de clé à serrure 2, record 1, French, relation%20de%20cl%C3%A9%20%C3%A0%20serrure
correct, feminine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Modèle de complémentarité structurale évoqué par E. Fischer qui implique une structure rigide de l'enzyme, s'adaptant rigoureusement à son substrat. Cependant, les variations d'entropie, relativement élevées, observées lors de la formation du complexe enzyme-substrat, ont conduit à admettre que ce processus est accompagné de changements de conformation des molécules. 2, record 1, French, - mod%C3%A8le%20clef%2Dserrure
Record number: 1, Textual support number: 1 CONT
Les enzymes montrent une grande spécificité à l'égard de leur substrat et souvent, elles n'accepteront pas de molécules apparentées dont la conformation est légèrement différente. Ceci peut s'expliquer en supposant que l'enzyme et le substrat ont une relation de clé à serrure. [...] L'enzyme possède un site actif complémentaire de la forme du substrat. Si la conformation du substrat est différente, il ne sera pas lié. 3, record 1, French, - mod%C3%A8le%20clef%2Dserrure
Record 1, Spanish
Record 1, Textual support, Spanish
Record 2 - internal organization data 1989-01-09
Record 2, English
Record 2, Subject field(s)
- Molecular Biology
Record 2, Main entry term, English
- lock-and-key interaction
1, record 2, English, lock%2Dand%2Dkey%20interaction
correct
Record 2, Abbreviations, English
Record 2, Synonyms, English
Record 2, Textual support, English
Record number: 2, Textual support number: 1 CONT
Enzymes have great specificity for their substrates and will frequently not accept related molecules of a slightly different shape. This can be explained by assuming that enzyme and substrate have a lock-and-key interaction. 1, record 2, English, - lock%2Dand%2Dkey%20interaction
Record 2, French
Record 2, Domaine(s)
- Biologie moléculaire
Record 2, Main entry term, French
- relation de clé à serrure
1, record 2, French, relation%20de%20cl%C3%A9%20%C3%A0%20serrure
correct, feminine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
Record 2, Textual support, French
Record number: 2, Textual support number: 1 CONT
Les enzymes montrent une grande spécificité à l'égard de leur substrat et souvent, elles n'accepteront pas de molécules apparentées dont la conformation est légèrement différente. Ceci peut s'expliquer en supposant que l'enzyme et le substrat ont une relation de clé à serrure. 1, record 2, French, - relation%20de%20cl%C3%A9%20%C3%A0%20serrure
Record 2, Spanish
Record 2, Textual support, Spanish
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