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ANALOGUE STRUCTURAL [2 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2009-02-16

English

Subject field(s)
  • Biochemistry
  • Molecular Biology
  • Genetics
DEF

An analogue of a purine or pyrimidine base, as aminopurine.

CONT

One of the most powerful base analogue mutagens is 5-bromouracil, an analogue of thymine. It is believed to cause mutations because its hydrogen atom at position 1 is not as firmly fixed as the corresponding hydrogen atom in thymine. Sometimes this hydrogen atom is bonded to the oxygen atom attached to carbon atom 6. When this happens, the 5-bromouracil can pair with guanine.

OBS

This phenomenon can lead to incorrect base pairing.

French

Domaine(s)
  • Biochimie
  • Biologie moléculaire
  • Génétique
DEF

Molécule de structure voisine de celles des bases azotées de l'A.D.N. ou de l'A.R.N. auxquelles elle peut se substituer. (Certains analogues de base, tel le 5-bromo-uracile, sont des agents mutagènes.)

Spanish

Campo(s) temático(s)
  • Bioquímica
  • Biología molecular
  • Genética
Save record 1

Record 2 2004-12-06

English

Subject field(s)
  • Chemical Engineering
  • Medication
CONT

Compounds structurally related to a particular biologically active compound have been observed to antagonize the biological action of the latter. ... Most structural analogues of a biologically active compound are inert, many are antagonists, but some actually replace the natural active compound in performing the same biological functions.

OBS

analogue: A chemical compound with a structure similar to that of another but differing from it in respect to a certain component; it may have a similar or opposite action metabolically.

French

Domaine(s)
  • Génie chimique
  • Médicaments
DEF

Composé chimique différant d'un médicament soit par remplacement d'une ou de plusieurs fonctions chimiques présentes par des fonctions plus ou moins semblables, soit par des modifications du squelette carboné.

CONT

[Le] but recherché est l'amélioration des performances thérapeutiques du principe actif originel; cette amélioration s'obtient par synthèse d'analogues structuraux ou de dérivés précurseurs (prodrogues). Les analogues structuraux, bien que proches du prototype de départ, sont des entités chimiques différentes présentant une activité biologique spécifique de la molécule qui les constitue.

OBS

Quoique les articles de la publication SCIAM-F soient pour la plupart des traductions de la revue "Scientific American", le contexte ci-haut n'a pas été pris dans un article traduit.

Spanish

Campo(s) temático(s)
  • Ingenieria química
  • Medicamentos
Save record 2

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