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CMH CLASSE I [1 record]

Record 1 1993-03-02

English

Subject field(s)
  • Immunology
DEF

(Each of) major histocompatibility antigens found on virtually every cell, human erythrocytes being the only notable exception; they are found on molecules consisting of two noncovalently bound chains. One on 44,000-dalton polymorphic glycoprotein partially embedded in the cell membrane, is determined by an MHC gene(HLA-A, -B, or -C in humans); the other, [beta]2-microglobulin, a 12,000-dalton nonopolymorphic protein, is determined by a non-MHC gene. Class I antigens are the classic histocompatibility antigens recognized during graft rejection....

DEF

Histocompatibility antigen composed of two non-covalently associated, glycosylated polypeptides: a heavy chain of M. Wt. 44 000 and beta squared-microglobulin, M. Wt. 12 000.

French

Domaine(s)
  • Immunologie
CONT

Différentes approches ont permis de définir deux catégories d'antigènes d'histocompatibilité : les antigènes de classe I qui stimulent puis qui sont la cible de la réaction de lymphocytotoxicité due aux cellules T et les antigènes de classe II (...). (...) Les antigènes de classe I ont une distribution tissulaire ubiquitaire sur les cellules diploïdes (...). Les antigènes de classe I sont composés d'une chaîne lourde polymorphe (45 kDa) codée dans le CMH, associée à la [bêta]2-microglobuline non polymorphe qui est codée en dehors du CMH.

CONT

(...) la plupart des cellules cytotoxiques reconnaissent les antigènes viraux en association avec les antigènes de classe I ce qui conforte cette hypothèse, puisque ces antigènes sont présents sur la majorité des cellules.

Spanish

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