TERMIUM Plus^®

Record 1,  Textual support,  English

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Récepteur de synthèse conçu pour n'être activé que par un ou par plusieurs ligands synthétiques, qui permet de contrôler l'activité des cellules qui l'expriment.  1, record 1, French, - r%C3%A9cepteur%20artificiel%20activ%C3%A9%20par%20ligand%20de%20synth%C3%A8se

Record number: 1, Textual support number: 1 OBS

récepteur artificiel activé par ligand de synthèse; RALS : désignations et définition publiées au Journal officiel de la République française le 27 juillet 2023.  3, record 1, French, - r%C3%A9cepteur%20artificiel%20activ%C3%A9%20par%20ligand%20de%20synth%C3%A8se

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

[A screening method] which applies computational descriptors of molecular structure, properties, or pharmacophore features to analyze relationships between active templates and compounds from chemical libraries ...  4, record 2, English, - ligand%2Dbased%20virtual%20screening

Record number: 2, Textual support number: 1 CONT

A common assumption in drug design is that two compounds with similar chemical property also exhibit similar biological effect. This is the main principle and motivation of ligand-based virtual screening.  5, record 2, English, - ligand%2Dbased%20virtual%20screening

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Criblage virtuel basé sur la structure du ligand. [...] Le but est de rechercher des molécules d'une chimiothèque dont la forme et le placement des fonctions chimiques ressemblent à la molécule de départ (substrat ou molécule active). Ces recherches ne nécessitent pas d'avoir la connaissance de la structure de la cible [...]  1, record 2, French, - criblage%20virtuel%20bas%C3%A9%20sur%20la%20structure%20du%20ligand

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  French

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

Trimebutine is so far the only drug that has been shown in clinical trials to be effective against irritable bowel. However, a unique drug called Fedotozine, a new opioid receptor ligand is undergoing a multicenter clinical trial in Canada.  1, record 4, English, - opioid%20receptor%20ligand

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 OBS

Ligand: Toute molécule capable de s'attacher à un récepteur cellulaire.  1, record 4, French, - ligand%20du%20r%C3%A9cepteur%20opio%C3%AFde

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

Molecular endocrinology and gene expression. Functional organization of the estrogen receptor and its involvement in mammary carcinogenesis. Estrogens and estrogen antagonists represent a group of clinically useful hormones and drugs that act through a nuclear receptor to modulate the transcriptional activity of a set of genes involved most notably in female reproductive physiology. The receptor for estrogens belongs to a superfamily of intracellular receptors that mediate the effects of the other gonadal and adrenal steroids, retinoids, thyroid hormones, and vitamin D. Common features shared by the intracellular receptors include organization into discrete functional domains responsible for ligand recognition, sequence-specific DNA binding, nuclear localization, and activation of transcription.  1, record 5, English, - sequence%20specific%20DNA%20binding%20ligand

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

Les profils ou patterns compositionnels des génomes des vertébrés. Histogrammes montrant les quantités relatives, les densités de flottaison modales et les niveaux des GC des composants majeurs de l'ADN chez le xénope, le poulet, la souris et l'homme, estimés après le fractionnement d'ADN par centrifugation préparative en gradient de densité en présence de ligands séquence-spécifiques.  1, record 5, French, - ligand%20s%C3%A9quence%2Dsp%C3%A9cifique

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

The biotic ligand model (BLM) ... is a tool used to evaluate quantitatively the manner in which several water chemistry parameters affect the speciation and bioavailability of metals in aquatic systems.  2, record 6, English, - biotic%20ligand%20model

Record number: 6, Textual support number: 1 OBS

biotic ligand model: term used by Environment Canada.  3, record 6, English, - biotic%20ligand%20model

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

Le modèle du ligand biotique (modèle BLM) [...] est un outil qui évalue quantitativement la manière dont plusieurs paramètres liés à la chimie de l'eau influent sur la spéciation et la biodisponibilité des métaux dans les systèmes aquatiques.  2, record 6, French, - mod%C3%A8le%20du%20ligand%20biotique

Record number: 6, Textual support number: 1 OBS

modèle du ligand biotique : terme en usage à Environnement Canada.  3, record 6, French, - mod%C3%A8le%20du%20ligand%20biotique

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

A molecule, ion, or atom that is attached to the central atom of a coordination compound, a chelate, or other complex.  2, record 7, English, - ligand

Record number: 7, Textual support number: 1 CONT

The Lewis Theory has been used extensively in the interpretation of the formation of coordination compounds in which the ligand is the base and the metal ion or ligand acceptor is the acid.  3, record 7, English, - ligand

Record number: 7, Textual support number: 1 OBS

Apart from its conventional usage in complexometry and with chelating ion exchange columns the word ligand is employed in affinity chromatography with reference to the biospecific material which is coupled to the polymetric carrier to form the biospecific column.  4, record 7, English, - ligand

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

Atome, ion ou molécule associé à l'atome central dans un complexe.  3, record 7, French, - ligand

Record number: 7, Textual support number: 1 CONT

Nous désignons par «coordinat» un atome, ou groupement d'atomes, chargé ou non, intervenant dans la formation de la liaison coordinative.  4, record 7, French, - ligand

Record number: 7, Textual support number: 1 PHR

Ligand ambidentate, hexadentate, monodentate, multidentate, polydentate, tétradentate, tridentate, unidentate; ligand dur, mou; ligand axial, donneur, pontant.  5, record 7, French, - ligand

Record number: 7, Textual support number: 2 PHR

Métal-ligand.  5, record 7, French, - ligand

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

Formation des complexes de coordination. Différents types de ligands : 1. Ligands monodentates : Ligands qui possèdent un seul site de fixation à l'atome métallique. Ils cèdent au métal central un doublet non liant avec création d'une liaison, exemples : ammine (NH₂, aqua(H₂O), carbonyl(CO), ligands soufrés (RSH, RS-) [et] 2. Ligands polydentates (ou chélatants) : Ligands qui possèdent plusieurs sites de fixation à l'atome métallique. Ils peuvent donner naissance à un chélate, un complexe où le ligand forme un cycle qui comprend l'atome métallique, exemples : glycinato (bidentate), éthylènediaminetétraacéto (EDTA, hexadentate) [...]  1, record 8, French, - ligand%20monodentate

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

L'ion oxalate et l'éthylènediamine sont des chélates appelés ligands bidentates car ils possèdent deux groupements susceptibles de former des liaisons coordinatives avec un métal.  2, record 9, French, - ligand%20bidentate

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 DEF

A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme.  2, record 10, English, - ligand

Record number: 10, Textual support number: 1 CONT

The immobilization of a ligand is carried out by the carrier-binding method in many cases ... Immobilization of a ligand on a carrier should be carried out via a reactive group in the ligand molecule which does not participate in affinity binding with the substance to be purified, as in the case of immobilization of enzymes.  3, record 10, English, - ligand

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 CONT

Les enzymes allostériques [...] possèdent sur chaque monomère plusieurs sites spécifiques, dits sites allostériques, pour la fixation de différents ligands, dont le substrat. En se fixant sur l'enzyme, ces ligands entraînent une modification de la configuration du site de fixation du substrat. Ils facilitent ou défavorisent la liaison du substrat à l'enzyme, agissant comme régulateur du fonctionnement de l'enzyme. On dit qu'il existe un effet de coopérativité entre les sites.  2, record 10, French, - ligand

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  French

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 OBS

Le petit sillon de l'ADN [acide désoxyribonucléique].  1, record 12, French, - ligand%20du%20petit%20sillon

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 OBS

(In La Recherche, Decembre 1991, vol. 22, issue number 238, p. 1428.)  1, record 13, English, - Diazepam%20Binding%20Inhibitor

Record 13,  Textual support,  French

Record 13,  Textual support,  Spanish