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LSA-1 [1 record]

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Record 1 2010-04-20

English

Subject field(s)
  • Genetics
CONT

OBS: LSA-1: Molecular weight: (190 KD - 230 KD) ... origin: Plasmodium falciparum ... Results of in vitro experiments: Inhibition of sporozoite invasion : not done; assay erythrocyte invasion: not done; lymphocyte proliferation: yes, cytotoxic T-cell activity: yes

French

Domaine(s)
  • Génétique
CONT

[...] les LTC (lymphocytes T cytotoxiques) pourraient intervenir dans la résistance au paludisme en détruisant les cellules infectées avant que les manifestations cliniques apparaissent. Pour tester cette hypothèse, les chercheurs ont synthétisé 70 peptides longs de 8 à 10 acides aminés et correspondant à des fragments de quatre antigènes plasmodiaux: LSA-1 (liver stage antigen 1), TRAP (thrombospondin related anonymous protein) et STARP (sporozoite threonine and asparagine rich protein).

Spanish

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