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MALADIE ANTI-MBG [2 records]

Record 1 2016-01-15

English

Subject field(s)
  • Immunology
  • Urinary Tract
  • The Lungs
DEF

A syndrome of glomerulonephritis, pulmonary hemorrhage, and circulating antibodies against basement membrane antigens.

OBS

It usually occurs in young men and is characterized by rapidly progressing renal failure as well as hemoptysis, pulmonary infiltrates, and dyspnea.

Key term(s)
  • Goodpasture's syndrome

French

Domaine(s)
  • Immunologie
  • Appareil urinaire
  • Poumons
CONT

Glomérulonéphrites auto-immunes. [...] Dans la forme la plus classique du syndrome de Goodpasture, la glomérulonéphrite est associée à une pneumopathie hémoptoïque. L'atteinte rénale se traduit par une insuffisance rénale, en général rapidement progressive avec, sur la biopsie rénale, des images de glomérulonéphrites nécrotiques. [...] L'immunofluorescence révèle le signe caractéristique de la maladie, la présence de dépôts linéaires continus d'immunoglobulines (et parfois de complément) le long de la membrane basale glomérulaire.

OBS

MBG : membrane basale glomérulaire.

Spanish

Campo(s) temático(s)
  • Inmunología
  • Vías urinarias
  • Pulmones
Save record 1

Record 2 2006-05-05

English

Subject field(s)
  • Immunology
DEF

Glomerulonephritis, usually of a generalized proliferative crescent-forming histologic type with a rapidly progressive course, marked by circulating anti-GBM antibodies and linear deposits of immunoglobulin and complement along the glomerular basement membrane. When associated with pulmonary hemorrhage, the condition is called Goodpasture's syndrome.

OBS

In the Merck Manual, these two diseases are synonymous.

French

Domaine(s)
  • Immunologie
CONT

Glomérulonéphrites auto-immunes. La plupart des glomérulonéphrites ont une origine immunitaire. Si le dépôt ou la formation locale de complexes immuns représente le mécanisme le plus fréquemment en cause, l'action néphrotoxique d'autoanticorps dirigés contre la membrane basale glomérulaire (GBM) a été bien démontrée chez certains malades.

Spanish

Campo(s) temático(s)
  • Inmunología
Save record 2

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