TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

A surrogate endpoint is a laboratory measure or a physical sign that is intended to be used as a substitute for an endpoint measuring a direct, meaningful clinical outcome (clinical outcome assessment or COA). A surrogate endpoint does not measure the expected clinical benefit of the therapy being studied directly, but rather is expected to predict that clinical benefit. For example, intraocular pressure is a surrogate endpoint for loss of vision in studies involving therapies to treat glaucoma.  3, record 1, English, - surrogate%20endpoint

Record number: 1, Textual support number: 1 OBS

surrogate marker: [According to some authors, the term "surrogate marker" should not be used, as] it suggests the substitution is for a marker rather than for a clinical endpoint.  4, record 1, English, - surrogate%20endpoint

Record number: 1, Textual support number: 2 OBS

surrogate endpoint: designation standardized by the Health Technology Assessment (HTA) Glossary English Editorial Board and the Translation Bureau.  5, record 1, English, - surrogate%20endpoint

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Un critère de jugement de substitution [...] est un critère qui n'est pas clinique et qui va être utilisé à la place d'un critère clinique. Il ne mesure donc pas un bénéfice clinique, il mesure un biomarqueur qui est un paramètre objectivement mesuré comme indicateur du processus de la maladie.  6, record 1, French, - crit%C3%A8re%20de%20jugement%20de%20substitution

Record number: 1, Textual support number: 1 OBS

indicateur de substitution : désignation normalisée par l'Institut national d'excellence en santé et en services sociaux (INESSS) et le Bureau de la traduction.  7, record 1, French, - crit%C3%A8re%20de%20jugement%20de%20substitution

Record number: 1, Textual support number: 2 OBS

marqueur de substitution : désignation publiée au Journal officiel de la République française le 24 octobre 2012.  8, record 1, French, - crit%C3%A8re%20de%20jugement%20de%20substitution

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

Refers to a judgment made by a surrogate decision-maker on behalf of an incompetent individual according to what the surrogate decision-maker believes would be the wishes of the incompetent individual were the individual competent.  2, record 2, English, - substituted%20judgment

Record number: 2, Textual support number: 1 CONT

The primary purpose of the substituted judgment test is to attempt to determine what decision the mental incompetent would make, if she were reviewing her situation as a competent person, but taking account of her mental incapacity as one factor in her decision.  3, record 2, English, - substituted%20judgment

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

[...] le critère [...] du jugement substitué [...] consiste à favoriser la décision que le patient incapable aurait lui-même prise s'il était capable.  4, record 2, French, - jugement%20substitu%C3%A9

Record 2,  Textual support,  Spanish