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TESTE AMES [1 record]
Record 1 - internal organization data 2012-12-07
Record 1, English
Record 1, Subject field(s)
- Biochemistry
Record 1, Main entry term, English
- Ames test
1, record 1, English, Ames%20test
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
This test for mutagenicity, now called the Ames test, has found wide but not yet official use as a test for carcinogenicity on the simple presumption that what can cause a mutation is overwhelmingly likely also to be able to cause cancer. 2, record 1, English, - Ames%20test
Record 1, French
Record 1, Domaine(s)
- Biochimie
Record 1, Main entry term, French
- test d'Ames
1, record 1, French, test%20d%27Ames
masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- essai d'Ames 2, record 1, French, essai%20d%27Ames
masculine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
Lorsque Bruce Ames a ouvert la voie qui allait conduire aux tests actuels des cancérigènes potentiels, il a, parmi les diverses manifestations cellulaires consécutives aux lésions du DNA, choisi d'utiliser la mutagénèse des bactéries. Le tests d'Ames, aujourd'hui classique, combine l'usage d'une bactérie et celui d'un extrait de foie de rat. L'organisme qui sert de «cobaye» est une bactérie, Salmonella typhimurium, porteuse d'une mutation (his-) qui l'a rendue incapable de fabriquer l'une des enzymes nécessaires à la synthèse de l'acide aminé histidine, composant indispensable des protéines. 1, record 1, French, - test%20d%27Ames
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Bioquímica
Record 1, Main entry term, Spanish
- prueba de Ames
1, record 1, Spanish, prueba%20de%20Ames
correct, feminine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 CONT
Prueba de Ames. Prueba de mutagenicidad en la cual una cepa de salmonella typhimurium mutante, caracterizada por su incapacidad para sintetizar histidina, se expone a un material que se va a ensayar, en un medio de cultivo que no contiene histidina. Si alguna de las bacterias recupera la capacidad de sintetizar la histidina y en consecuencia forma colonias, se comprueba que el material sometido a prueba tiene propiedades mutagénicas. Se pueden usar cepas de otras bacterias (por ejemplo: escherichia coli). 1, record 1, Spanish, - prueba%20de%20Ames
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