TERMIUM Plus®

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BASE ANALOG [1 record]

Record 1 2009-02-16

English

Subject field(s)
  • Biochemistry
  • Molecular Biology
  • Genetics
DEF

An analogue of a purine or pyrimidine base, as aminopurine.

CONT

One of the most powerful base analogue mutagens is 5-bromouracil, an analogue of thymine. It is believed to cause mutations because its hydrogen atom at position 1 is not as firmly fixed as the corresponding hydrogen atom in thymine. Sometimes this hydrogen atom is bonded to the oxygen atom attached to carbon atom 6. When this happens, the 5-bromouracil can pair with guanine.

OBS

This phenomenon can lead to incorrect base pairing.

French

Domaine(s)
  • Biochimie
  • Biologie moléculaire
  • Génétique
DEF

Molécule de structure voisine de celles des bases azotées de l'A.D.N. ou de l'A.R.N. auxquelles elle peut se substituer. (Certains analogues de base, tel le 5-bromo-uracile, sont des agents mutagènes.)

Spanish

Campo(s) temático(s)
  • Bioquímica
  • Biología molecular
  • Genética
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