TERMIUM Plus®

The Government of Canada’s terminology and linguistic data bank.

JOINING REGION [1 record]

Record 1 2006-05-08

English

Subject field(s)
  • Immunology
DEF

The portion of an immunoglobulin heavy chain between the Fc and Fab regions, which permits flexibility within the molecule and allows the two combining sites to operate independently. The hinge region is usually encoded by a separate exon.

DEF

hinge region: a region in the immunoglobulin molecule particularly exposed to the action of proteinases. In immunoglobulin G, it is in the heavy chains close to the attachment of the light chains. There is flexibility in this region, and the Fab region, which binds antigens, can move such as fixation of complement.

French

Domaine(s)
  • Immunologie
DEF

Partie de la chaîne lourde d'immunoglobuline entre le Fc et le Fab. La région charnière permet la flexibilité de la molécule et permet aux deux sites de liaison de l'immunoglobuline d'agir indépendamment. La région charnière est habituellement codée par un exon particulier.

CONT

Il existe, proche du milieu des chaînes lourdes, un court segment d'environ 15 aminoacides, où se situent tous les résidus cystéine impliqués dans la formation des ponts S-S reliant les chaînes lourdes. Ce segment, appelé région charnière, ne présente pas d'homologie avec les autres domaines.

Spanish

Campo(s) temático(s)
  • Inmunología
Save record 1

Copyright notice for the TERMIUM Plus® data bank

© Public Services and Procurement Canada, 2024
TERMIUM Plus®, the Government of Canada's terminology and linguistic data bank
A product of the Translation Bureau

Features

Language Portal of Canada

Access a collection of Canadian resources on all aspects of English and French, including quizzes.

Writing tools

The Language Portal’s writing tools have a new look! Easy to consult, they give you access to a wealth of information that will help you write better in English and French.

Glossaries and vocabularies

Access Translation Bureau glossaries and vocabularies.

Date Modified: