TERMIUM Plus®

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TUMOR INITIATOR [1 record]

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Filter results by subject field

Alphabetical list of terms

Record 1 2015-09-01

English

Subject field(s)
  • Cytology
  • Cancers and Oncology
  • Toxicology
DEF

... an agent which increases the rate of occurrence ... of the first genetic event [leading to the] cellular transformation to a malignant state ...

CONT

Initiation is the first step in the two-stage model of cancer development. Initiators cause irreversible changes (mutations) to DNA that increase cancer risk. ... Once a cell has been mutated by an initiator, it is susceptible to the effects of promoters [that] increase the proliferation of cells ...

Key term(s)
  • tumour initiator

French

Domaine(s)
  • Cytologie
  • Cancers et oncologie
  • Toxicologie
DEF

Agent provoquant le premier stade de la cancérogénèse.

CONT

[L']initiation tumorale [est un] processus irréversible résultant de l'exposition des cellules à une dose appropriée d'un agent carcinogène dit initiateur qui produit une modification permanente de l'ADN de ces cellules cibles, lesquelles pourront donner naissance à une tumeur par action complémentaire d'un promoteur.

Spanish

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TERMIUM Plus®, the Government of Canada's terminology and linguistic data bank
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