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TUMOR PROMOTER [1 record]

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Record 1 2012-01-13

English

Subject field(s)
  • Cytology
  • Cancers and Oncology
DEF

[An] epigenetic carcinogen that promotes neoplastic growth only after initiation by another substance.

CONT

Promotion is the second step in the two-stage model of cancer development. Once a cell has been mutated by an initiator, it is susceptible to the effects of promoters. Promoters increase the proliferation of cells ...

OBS

Tumor promoters are not able to cause tumors to form.

OBS

[The] promoting agent ... may of itself be noncarcinogenic.

Key term(s)
  • tumour promotor
  • tumor promotor
  • tumour promoter

French

Domaine(s)
  • Cytologie
  • Cancers et oncologie
DEF

[...] substance non tumorigène par elle-même mais capable d'induire une tumeur à partir de cellules initiées.

CONT

Les cellules cancéreuses se développent à partir de cellules saines par un processus complexe [dont la] première étape, appelée initiation, permet l'intégration d'une anomalie du matériel génétique d'une cellule [...] pour que la cellule devienne maligne. [...] La seconde et dernière étape du développement d'une tumeur est appelée promotion. Les agents responsables, dits promoteurs, [...] permettent à la cellule qui a subi l'initiation de devenir cancéreuse.

OBS

[...] les tumeurs ne se développent pas lorsque l'agent promoteur est appliqué avant et non après l'agent initiateur.

Spanish

Campo(s) temático(s)
  • Citología
  • Tipos de cáncer y oncología
DEF

Sustancia química que estimula la transformación de células benignas en cancerosas.

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