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INHIBITEUR ANGIOGENESE [5 records]
Record 1 - internal organization data 2011-12-14
Record 1, English
Record 1, Subject field(s)
- Medication
Record 1, Main entry term, English
- multi-target drug
1, record 1, English, multi%2Dtarget%20drug
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- dirty drug 2, record 1, English, dirty%20drug
correct, familiar, pejorative
- promiscuous drug 2, record 1, English, promiscuous%20drug
familiar, pejorative
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
Sutent (SU11248) is a relatively "dirty" drug (in that it hits multiple targets) and has some affinity for 74 different kinases. PTK787 was one of the "cleanest" drugs tested in this study ... Being a "dirty" drug is not necessarily a bad thing. … The trick is that most cancers have more than one target. They might have five or six targets and you have to knock out three to stop the cancer ... 3, record 1, English, - multi%2Dtarget%20drug
Record number: 1, Textual support number: 2 CONT
The rationale for multi-target drugs has been strengthened both on theoretical and empirical grounds. Serious diseases that are intractable to treatment were found to have multiple pathogenic factors and examples of successful drugs were shown to affect multiple disease targets. The salient features of multiple-target drugs, low target affinity and rapid binding kinetics, have been responsible for their late discovery and slow development. 4, record 1, English, - multi%2Dtarget%20drug
Record 1, French
Record 1, Domaine(s)
- Médicaments
Record 1, Main entry term, French
- médicament multicible
1, record 1, French, m%C3%A9dicament%20multicible
correct, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
La première activité décrite du sorafénib était celle d’inhibiteur de sérine/thréonine kinase de la protéine Raf-1. Par la suite, les autres cibles ont été successivement identifiées. En bloquant plusieurs voies de transduction différentes, ces médicaments multicibles présentent donc l'intérêt d’avoir une action prédominante sur l'angiogenèse mais aussi sur la prolifération cellulaire et l'apoptose. 2, record 1, French, - m%C3%A9dicament%20multicible
Record 1, Spanish
Record 1, Textual support, Spanish
Record 2 - internal organization data 1999-06-16
Record 2, English
Record 2, Subject field(s)
- Genetics
Record 2, Main entry term, English
- targetted antiangiogenesis
1, record 2, English, targetted%20antiangiogenesis
proposal
Record 2, Abbreviations, English
Record 2, Synonyms, English
Record 2, Textual support, English
Record 2, French
Record 2, Domaine(s)
- Génétique
Record 2, Main entry term, French
- anti-angiogénèse ciblée
1, record 2, French, anti%2Dangiog%C3%A9n%C3%A8se%20cibl%C3%A9e
correct, feminine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
Record 2, Textual support, French
Record number: 2, Textual support number: 1 CONT
Le travail de l'équipe de Robert J. d’Amato et celui du groupe de Howard Fine, du Dana-Farber Institute(Boston), se ressemblent sur um point : l'idée de bloquer la croissance vasculaire, ou angiogénèse, pour retarder le développement tumoral. Mais là s’arrête la similitude. L'objectif de l'équipe de H Fine est d’améliorer le mode de délivrance des anti-antigiogènes, tels que le PF4, ou platelet factor 4, un inhibiteur puissant de la prolifération des cellules endothéliales in vitro et de l'angiogénèse in vivo, dont l'efficacité antitumorale relative à ce type de traitement constitue en tout cas une piste prometteuse : alors que le traitement par médication classique n’ atteint qu'un nombre faible de cellules et impose une prise continue, la stratégie du PF4 permet à toute une zone de produire son agent anti-angiogène. Les chercheurs américains l'ont baptisée «anti-angiogénèse ciblée». 1, record 2, French, - anti%2Dangiog%C3%A9n%C3%A8se%20cibl%C3%A9e
Record number: 2, Textual support number: 1 OBS
Traitement des tumeurs par antiangiogénèse 2, record 2, French, - anti%2Dangiog%C3%A9n%C3%A8se%20cibl%C3%A9e
Record 2, Spanish
Record 2, Textual support, Spanish
Record 3 - internal organization data 1999-03-26
Record 3, English
Record 3, Subject field(s)
- Biochemistry
Record 3, Main entry term, English
- angiogenesis inhibitor
1, record 3, English, angiogenesis%20inhibitor
correct
Record 3, Abbreviations, English
Record 3, Synonyms, English
Record 3, Textual support, English
Record number: 3, Textual support number: 1 CONT
Folkman and his prolific laboratory hit the news in the major way this past May, when an overenthusiastic, frontpage story in the New York Times trumpeted results by Folkman's group using naturally derived angiogenesis inhibitors to cure cancer in mice by preventing the growing tumors from attaining a blood supply. 1, record 3, English, - angiogenesis%20inhibitor
Record 3, French
Record 3, Domaine(s)
- Biochimie
Record 3, Main entry term, French
- inhibiteur d'angiogenèse
1, record 3, French, inhibiteur%20d%27angiogen%C3%A8se
correct, masculine noun
Record 3, Abbreviations, French
Record 3, Synonyms, French
Record 3, Textual support, French
Record number: 3, Textual support number: 1 CONT
Les Laboratoires AEterna inc. annonce qu'elle a isolé une molécule aux propriétés antimétalloprotéases(anti-MMP) de faible poids moléculaire dans le cadre du programme de caractérisation de l'inhibiteur d’angiogenèse(AE-941), et déposé une demande de brevet afin de protéger cette molécule active ainsi que ses applications potentielles. «L'isolation d’une molécule anti-MMP de faible poids moléculaire marque un jalon important dans la compréhension du mécanisme d’action du AE-941 sur l'angiogenèse impliquée dans le cancer », a déclaré le Dr Pierre Falardeau, directeur scientifique d’AEterna, lors du congrès de l'American Chemical Society à Boston(États-Unis) où il présentait, à titre de conférencier invité, le programme de caractérisation du AE-941. 1, record 3, French, - inhibiteur%20d%27angiogen%C3%A8se
Record 3, Spanish
Record 3, Textual support, Spanish
Record 4 - internal organization data 1999-03-19
Record 4, English
Record 4, Subject field(s)
- Biochemistry
Record 4, Main entry term, English
- endostatin
1, record 4, English, endostatin
correct
Record 4, Abbreviations, English
Record 4, Synonyms, English
Record 4, Textual support, English
Record number: 4, Textual support number: 1 CONT
Cancer cures come and go, yet many cancers are now fully treatable with impressive results. On 5 May 1998 the Head of the US National Cancer Institute Dr Richard Klausner declared a major breakthrough in research with two new drugs, endostatin and angiostatin. Endostatin prevents growth of cancer cells, while angiostatin stops blood vessel formation in or next to cancer growths. 1, record 4, English, - endostatin
Record 4, French
Record 4, Domaine(s)
- Biochimie
Record 4, Main entry term, French
- endostatine
1, record 4, French, endostatine
correct, feminine noun
Record 4, Abbreviations, French
Record 4, Synonyms, French
Record 4, Textual support, French
Record number: 4, Textual support number: 1 CONT
Les tumeurs cancéreuses solides ne peuvent se développer sans «recruter» de nouveaux vaisseaux sanguins et ce processus d’angiogénèse est responsable d’un problème majeur dans le traitement des cancers : la résistance acquise aux médicaments. Une étude expérimentale conforte des espoirs suscités depuis quelques temps par la thérapie angiogénique. En traitant des souris atteintes de divers cancers par un inhibiteur spécifique de l'angiogenèse, l'endostatine, on peut véritablement «endormir» les tumeurs de façon prolongée. 1, record 4, French, - endostatine
Record 4, Spanish
Record 4, Textual support, Spanish
Record 5 - internal organization data 1998-10-27
Record 5, English
Record 5, Subject field(s)
- Biotechnology
Record 5, Main entry term, English
- angiogenic therapy
1, record 5, English, angiogenic%20therapy
correct
Record 5, Abbreviations, English
Record 5, Synonyms, English
Record 5, Textual support, English
Record number: 5, Textual support number: 1 CONT
Invasion and angiogenesis are the newest therapeutic targets to yield agents for phase I clinical trials. Three general strategies for anti-invasive/anti-angiogenic therapy have been proposed:(1)inhibition of the production of stimulatory factors by tumor cells, (2) blockade of invasive activity, and (3) interdiction of the signal directing the proliferative or invasive command. Growth factor antagonists, such as suramin, tyrphostins,78,79 and signal transduction inhibitors such as CAI (see below) and protein kinase C (PKC) inhibitors are all in clinical development. 1, record 5, English, - angiogenic%20therapy
Record 5, French
Record 5, Domaine(s)
- Biotechnologie
Record 5, Main entry term, French
- thérapie angiogénique
1, record 5, French, th%C3%A9rapie%20angiog%C3%A9nique
correct, feminine noun
Record 5, Abbreviations, French
Record 5, Synonyms, French
Record 5, Textual support, French
Record number: 5, Textual support number: 1 CONT
Les tumeurs cancéreuses solides ne peuvent se développer sans «recruter» de nouveaux vaisseaux sanguins et ce processus d’angiogénèse est responsable d’un problème majeur dans le traitement des cancers : la résistance acquise aux médicaments. Une étude expérimentale conforte des espoirs suscités depuis quelques temps par la thérapie angiogénique. En traitant des souris atteintes de divers cancers par un inhibiteur spécifique de l'angiogenèse, l'endostatine, on peut véritablement «endormir» les tumeurs de façon prolongée. 1, record 5, French, - th%C3%A9rapie%20angiog%C3%A9nique
Record 5, Spanish
Record 5, Textual support, Spanish
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