TERMIUM Plus®

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OPTIMISATION COMPOSE CHEF FILE [1 record]

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Record 1 2022-04-25

English

Subject field(s)
  • Pharmacology
  • Biotechnology
CONT

Lead optimization refers to the process of designing and improving a preidentified lead compound, and involves manipulation of multiple parameters of the compound, relying on chemical modifications to the compound. During this process, synthetic changes are made to optimize the compounds ADMET properties (absorption, distribution, metabolism, excretion, and toxicity) as well as the compound's activity, potency, and selectivity.

Key term(s)
  • lead compound optimisation
  • lead optimisation

French

Domaine(s)
  • Pharmacologie
  • Biotechnologie

Spanish

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